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ENZYME entry: EC 1.1.99.36
Accepted Name |
alcohol dehydrogenase (nicotinoprotein).
|
Alternative Name(s) |
NDMA-dependent alcohol dehydrogenase. |
nicotinoprotein alcohol dehydrogenase. |
Reaction catalysed |
A + ethanol <=> acetaldehyde + AH2 |
Comment(s) |
- Nicotinoprotein alcohol dehydrogenases are unique medium-chain
dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a
tightly bound NAD(+)/NADH cofactor that does not dissociate during
the catalytic process.
- Instead, the cofactor is regenerated by a second substrate or
electron carrier.
- While the in vivo electron acceptor is not known, N,N-dimethyl-4-
nitrosoaniline (NDMA) can serve this function in vitro.
- The enzyme from the Gram-positive bacterium Amycolatopsis methanolica
can accept many primary alcohols as substrates, including
benzylalcohol.
|
Cross-references |
BRENDA | 1.1.99.36 |
EC2PDB | 1.1.99.36 |
ExplorEnz | 1.1.99.36 |
PRIAM enzyme-specific profiles | 1.1.99.36 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.99.36 |
IUBMB Enzyme Nomenclature | 1.1.99.36 |
IntEnz | 1.1.99.36 |
MEDLINE | Find literature relating to 1.1.99.36 |
MetaCyc | 1.1.99.36 |
Rhea expert-curated reactions | 1.1.99.36 |
UniProtKB/Swiss-Prot |
|
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