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ENZYME entry: EC 1.1.99.36

Accepted Name
Alcohol dehydrogenase (nicotinoprotein).
Alternative Name(s)
NDMA-dependent alcohol dehydrogenase.
Nicotinoprotein alcohol dehydrogenase.
Reaction catalysed
Ethanol + acceptor <=> acetaldehyde + reduced acceptor
Cofactor(s)
Zn(2+).
Comment(s)
  • Nicotinoprotein alcohol dehydrogenases are unique medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a tightly bound NAD(+)/NADH cofactor that does not dissociate during the catalytic process.
  • Instead, the cofactor is regenerated by a second substrate or electron carrier.
  • While the in vivo electron acceptor is not known, N,N-dimethyl-4- nitrosoaniline (NDMA) can serve this function in vitro.
  • The enzyme from the Gram-positive bacterium Amycolatopsis methanolica can accept many primary alcohols as substrates, including benzylalcohol.
Cross-references
BRENDA1.1.99.36
EC2PDB1.1.99.36
ExplorEnz1.1.99.36
PRIAM enzyme-specific profiles1.1.99.36
KEGG Ligand Database for Enzyme Nomenclature1.1.99.36
IUBMB Enzyme Nomenclature1.1.99.36
IntEnz1.1.99.36
MEDLINEFind literature relating to 1.1.99.36
MetaCyc1.1.99.36
Rhea expert-curated reactions1.1.99.36
UniProtKB/Swiss-Prot
P80175, ADHN_AMYME;  P81747, ADHN_RHOER;  

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