ID   1.1.99.37
DE   methanol dehydrogenase (nicotinoprotein).
AN   NDMA-dependent methanol dehydrogenase.
AN   nicotinoprotein methanol dehydrogenase.
CA   A + methanol = AH2 + formaldehyde.
CC   -!- Nicotinoprotein methanol dehydrogenases have a tightly bound
CC       NADP+/NADPH cofactor that does not dissociate during the catalytic
CC       process.
CC   -!- Instead, the cofactor is regenerated by a second substrate or
CC       electron carrier.
CC   -!- While the in vivo electron acceptor is not known, N,N-dimethyl-4-
CC       nitrosoaniline (NDMA) can serve this function in vitro.
CC   -!- The enzyme has been detected in several Gram-positive methylotrophic
CC       bacteria, including Amycolatopsis methanolica, Rhodococcus
CC       rhodochrous and Rhodococcus erythropolis.
CC   -!- These enzymes are decameric, and possess a 5-fold symmetry.
CC   -!- Some of the enzymes can also dismutate formaldehyde to methanol and
CC       formate.
DR   Q9RCG0, MNO_AMYME  ;  C5MRT8, MNO_MYCS8  ;  Q53062, MNO_RHOER  ;
//