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ENZYME entry: EC 1.1.99.41

Accepted Name
3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase.
Alternative Name(s)
T3R.
Tabersonine 3-reductase.
Reaction catalysed
  • (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + acceptor <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor
  • (3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor <=> (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor
Comment(s)
  • This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle).
  • In vivo, it functions in the direction of reduction.
  • It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.
Cross-references
BRENDA1.1.99.41
EC2PDB1.1.99.41
ExplorEnz1.1.99.41
PRIAM enzyme-specific profiles1.1.99.41
KEGG Ligand Database for Enzyme Nomenclature1.1.99.41
IUBMB Enzyme Nomenclature1.1.99.41
IntEnz1.1.99.41
MEDLINEFind literature relating to 1.1.99.41
MetaCyc1.1.99.41
UniProtKB/Swiss-Prot
A0A161CAI1, T3R_CATRO

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