ENZYME entry: EC 1.1.99.41

Accepted Name

3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase

Alternative Name(s)

T3R

tabersonine 3-reductase

Reaction catalysed

(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2
(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2

Comment(s)

This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle).
In vivo, it functions in the direction of reduction.
It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

A0A161CAI1, T3R_CATRO

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