ID 1.1.99.7 DE lactate--malate transhydrogenase. CA (S)-lactate + oxaloacetate = (S)-malate + pyruvate. CC -!- Catalyzes hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to CC 2-oxo acids. CC -!- Contains tightly bound nicotinamide nucleotide in its active center. CC -!- This cofactor cannot be removed without denaturation of the protein. //