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ENZYME entry: EC 1.10.3.15

Accepted Name
Grixazone synthase.
Reaction catalysed
2 3-amino-4-hydroxybenzoate + N-acetyl-L-cysteine + 2 O(2) <=> grixazone B + 4 H(2)O + CO(2)
Cofactor(s)
Cu cation.
Comment(s)
  • The enzyme, isolated from the bacterium Streptomyces griseus, catalyzes an 8 electron oxidation.
  • Activation of the enzyme requires a copper chaperone (GriE).
  • It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A.
  • The second aldehyde group is presumably lost as formate.
  • The enzyme also catalyzes the reaction of EC 1.10.3.4.
Cross-references
BRENDA1.10.3.15
EC2PDB1.10.3.15
ExplorEnz1.10.3.15
PRIAM enzyme-specific profiles1.10.3.15
KEGG Ligand Database for Enzyme Nomenclature1.10.3.15
IUBMB Enzyme Nomenclature1.10.3.15
IntEnz1.10.3.15
MEDLINEFind literature relating to 1.10.3.15
MetaCyc1.10.3.15
Rhea expert-curated reactions1.10.3.15
UniProtKB/Swiss-Prot
B1VTI5, GRIF_STRGG

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