ENZYME entry: EC 1.10.3.15
| Accepted Name |
|---|
| Grixazone synthase.
|
| Reaction catalysed |
|---|
| 2 3-amino-4-hydroxybenzoate + N-acetyl-L-cysteine + 2 O(2) <=> grixazone B + 4 H(2)O + CO(2) |
| Cofactor(s) |
|---|
| Cu cation.
|
| Comment(s) |
|---|
- The enzyme, isolated from the bacterium Streptomyces griseus,
catalyzes an 8 electron oxidation.
- Activation of the enzyme requires a copper chaperone (GriE).
- It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A.
- The second aldehyde group is presumably lost as formate.
- The enzyme also catalyzes the reaction of EC 1.10.3.4.
|
| Cross-references |
|---|
| BRENDA | 1.10.3.15 |
| EC2PDB | 1.10.3.15 |
| ExplorEnz | 1.10.3.15 |
| PRIAM enzyme-specific profiles | 1.10.3.15 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.10.3.15 |
| IUBMB Enzyme Nomenclature | 1.10.3.15 |
| IntEnz | 1.10.3.15 |
| MEDLINE | Find literature relating to 1.10.3.15 |
| MetaCyc | 1.10.3.15 |
| UniProtKB/Swiss-Prot |
|
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