Expasy logo


ENZYME entry: EC

Accepted Name
chloride peroxidase
Alternative Name(s)
vanadium haloperoxidase
Reaction catalysed
RH + Cl(-) + H2O2 <=> RCl + 2 H2O
  • Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds.
  • Also oxidizes bromide and iodide.
  • Enzymes of this type are either heme-thiolate proteins, or contain vanadate.
  • A secreted enzyme produced by the ascomycetous fungus Caldariomyces fumago (Leptoxyphium fumago) is an example of the heme-thiolate type.
  • It catalyzes the production of hypochlorous acid by transferring one oxygen atom from H2O2 to chloride.
  • At a separate site it catalyzes the chlorination of activated aliphatic and aromatic substrates, via HClO and derived chlorine species.
  • In the absence of halides, it shows peroxidase (e.g. phenol oxidation) and peroxygenase activities.
  • The latter inserts oxygen from H2O2 into, for example, styrene (side chain epoxidation) and toluene (benzylic hydroxylation), however, these activities are less pronounced than its activity with halides.
  • Has little activity with non-activated substrates such as aromatic rings, ethers or saturated alkanes.
  • The chlorinating peroxidase produced by ascomycetous fungi (e.g. Curvularia inaequalis) is an example of a vanadium chloroperoxidase, and is related to bromide peroxidase (EC
  • It contains vanadate and oxidizes chloride, bromide and iodide into hypohalous acids.
  • In the absence of halides, it peroxygenates organic sulfides and oxidizes ABTS [2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid)] but no phenols.
PRIAM enzyme-specific profiles1.11.1.10
KEGG Ligand Database for Enzyme Nomenclature1.11.1.10
IUBMB Enzyme Nomenclature1.11.1.10
MEDLINEFind literature relating to
Rhea expert-curated reactions1.11.1.10

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-