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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.11.1.13

Accepted Name

Manganese peroxidase.

Alternative Name(s)

Mn-dependent peroxidase.

Reaction catalysed

2 Mn(2+) + 2 H(+) + H(2)O(2) <=> 2 Mn(3+) + 2 H(2)O

Cofactor(s)

Heme.

Comment(s)

The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin.
The enzyme oxidizes a bound Mn(2+) ion to Mn(3+) in the presence of hydrogen peroxide.
The product, Mn(3+), is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn(2+) and insoluble Mn(4+).
The complexed Mn(3+) ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates.
It is inactive with veratryl alcohol or nonphenolic substrates.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature