ENZYME entry: EC 1.11.1.13
Accepted Name |
Manganese peroxidase.
|
Alternative Name(s) |
Mn-dependent peroxidase. |
Reaction catalysed |
2 Mn(2+) + 2 H(+) + H(2)O(2) <=> 2 Mn(3+) + 2 H(2)O |
Cofactor(s) |
Heme.
|
Comment(s) |
- The enzyme from white rot basidiomycetes is involved in the oxidative
degradation of lignin.
- The enzyme oxidizes a bound Mn(2+) ion to Mn(3+) in the presence of
hydrogen peroxide.
- The product, Mn(3+), is released from the active site in the presence
of a chelator (mostly oxalate and malate) that stabilizes it against
disproportionation to Mn(2+) and insoluble Mn(4+).
- The complexed Mn(3+) ion can diffuse into the lignified cell wall,
where it oxidizes phenolic components of lignin and other organic
substrates.
- It is inactive with veratryl alcohol or nonphenolic substrates.
|
Cross-references |
PROSITE | PDOC00394 |
BRENDA | 1.11.1.13 |
EC2PDB | 1.11.1.13 |
ExplorEnz | 1.11.1.13 |
PRIAM enzyme-specific profiles | 1.11.1.13 |
KEGG Ligand Database for Enzyme Nomenclature | 1.11.1.13 |
IUBMB Enzyme Nomenclature | 1.11.1.13 |
IntEnz | 1.11.1.13 |
MEDLINE | Find literature relating to 1.11.1.13 |
MetaCyc | 1.11.1.13 |
Rhea expert-curated reactions | 1.11.1.13 |
UniProtKB/Swiss-Prot |
|
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