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ENZYME entry: EC 1.11.1.20

Accepted Name
prostamide/prostaglandin F2alpha synthase.
Alternative Name(s)
prostamide/PGF synthase.
prostamide/prostaglandin F synthase.
prostamide F synthase.
TPGF synthase.
Reaction catalysed
[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha
Comment(s)
  • The enzyme contains a thioredoxin-type disulfide as a catalytic group.
  • Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha.
  • The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
Cross-references
BRENDA1.11.1.20
EC2PDB1.11.1.20
ExplorEnz1.11.1.20
PRIAM enzyme-specific profiles1.11.1.20
KEGG Ligand Database for Enzyme Nomenclature1.11.1.20
IUBMB Enzyme Nomenclature1.11.1.20
IntEnz1.11.1.20
MEDLINEFind literature relating to 1.11.1.20
MetaCyc1.11.1.20
Rhea expert-curated reactions1.11.1.20
UniProtKB/Swiss-Prot
Q58CY6, PXL2B_BOVIN;  Q6NV24, PXL2B_DANRE;  Q8TBF2, PXL2B_HUMAN;  
C1C416, PXL2B_LITCT;  Q9DB60, PXL2B_MOUSE;  A9CQL8, PXL2B_PIG;  
Q5R7S9, PXL2B_PONAB;  D3ZVR7, PXL2B_RAT;  B5X9L9, PXL2B_SALSA;  
Q6AZG8, PXL2B_XENLA;  Q28IJ3, PXL2B_XENTR;  

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