ENZYME entry: EC 1.11.1.20
Accepted Name |
prostamide/prostaglandin F2alpha synthase.
|
Alternative Name(s) |
prostamide/PGF synthase. |
prostamide/prostaglandin F synthase. |
prostamide F synthase. |
TPGF synthase. |
Reaction catalysed |
[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha |
Comment(s) |
- The enzyme contains a thioredoxin-type disulfide as a catalytic
group.
- Prostamide H2 and prostaglandin H2 are the best substrates; the
latter is converted to prostaglandin F2alpha.
- The enzyme also reduces tert-butyl hydroperoxide, cumene
hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
|
Cross-references |
BRENDA | 1.11.1.20 |
EC2PDB | 1.11.1.20 |
ExplorEnz | 1.11.1.20 |
PRIAM enzyme-specific profiles | 1.11.1.20 |
KEGG Ligand Database for Enzyme Nomenclature | 1.11.1.20 |
IUBMB Enzyme Nomenclature | 1.11.1.20 |
IntEnz | 1.11.1.20 |
MEDLINE | Find literature relating to 1.11.1.20 |
MetaCyc | 1.11.1.20 |
Rhea expert-curated reactions | 1.11.1.20 |
UniProtKB/Swiss-Prot |
Q58CY6, PXL2B_BOVIN; | Q6NV24, PXL2B_DANRE; | Q8TBF2, PXL2B_HUMAN; |
C1C416, PXL2B_LITCT; | Q9DB60, PXL2B_MOUSE; | A9CQL8, PXL2B_PIG; |
Q5R7S9, PXL2B_PONAB; | D3ZVR7, PXL2B_RAT; | B5X9L9, PXL2B_SALSA; |
Q6AZG8, PXL2B_XENLA; | Q28IJ3, PXL2B_XENTR; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
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