A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.11.1.20
| Accepted Name |
|---|
| Prostamide/prostaglandin F(2-alpha) synthase.
|
| Alternative Name(s) |
|---|
| Prostamide F synthase. |
| Prostamide/PGF synthase. |
| Prostamide/prostaglandin F synthase. |
| TPGF synthase. |
| Reaction catalysed |
|---|
| Thioredoxin + prostaglandin H(2) <=> thioredoxin disulfide + prostaglandin F(2-alpha) |
| Comment(s) |
|---|
- The enzyme contains a thioredoxin-type disulfide as a catalytic
group.
- Prostamide H(2) and prostaglandin H(2) are the best substrates; the
latter is converted to prostaglandin F(2-alpha).
- The enzyme also reduces tert-butyl hydroperoxide, cumene
hydroperoxide and H(2)O(2), but not prostaglandin D(2) or
prostaglandin E(2).
|
| Cross-references |
|---|
| BRENDA | 1.11.1.20 |
| EC2PDB | 1.11.1.20 |
| ExplorEnz | 1.11.1.20 |
| PRIAM enzyme-specific profiles | 1.11.1.20 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.11.1.20 |
| IUBMB Enzyme Nomenclature | 1.11.1.20 |
| IntEnz | 1.11.1.20 |
| MEDLINE | Find literature relating to 1.11.1.20 |
| MetaCyc | 1.11.1.20 |
| UniProtKB/Swiss-Prot |
| Q58CY6, PXL2B_BOVIN; | Q6NV24, PXL2B_DANRE; | Q8TBF2, PXL2B_HUMAN; |
| C1C416, PXL2B_LITCT; | Q9DB60, PXL2B_MOUSE; | A9CQL8, PXL2B_PIG; |
| Q5R7S9, PXL2B_PONAB; | D3ZVR7, PXL2B_RAT; | B5X9L9, PXL2B_SALSA; |
| Q6AZG8, PXL2B_XENLA; | Q28IJ3, PXL2B_XENTR; |
|
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