ID   1.11.1.24
DE   thioredoxin-dependent peroxiredoxin.
AN   thioredoxin peroxidase.
CA   [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide +
CA   an alcohol + H2O.
CC   -!- Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant
CC       proteins.
CC   -!- They can be divided into three classes: typical 2-Cys, atypical 2-Cys
CC       and 1-Cys peroxiredoxins.
CC   -!- The peroxidase reaction comprises two steps centered around a redox-
CC       active cysteine called the peroxidatic cysteine.
CC   -!- All three peroxiredoxin classes have the first step in common,
CC       in which the peroxidatic cysteine attacks the peroxide substrate and
CC       is oxidized to S-hydroxycysteine (a sulfenic acid).
CC   -!- The second step of the peroxidase reaction, the regeneration of
CC       cysteine from S-hydroxycysteine, distinguishes the three
CC       peroxiredoxin classes.
CC   -!- For typical 2-Cys Prxs, in the second step, the peroxidatic
CC       S-hydroxycysteine from one subunit is attacked by the 'resolving'
CC       cysteine located in the C-terminus of the second subunit, to form an
CC       intersubunit disulfide bond, which is then reduced by one of several
CC       cell-specific thiol-containing reductants completing the catalytic
CC       cycle.
CC   -!- In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its
CC       resolving cysteine are in the same polypeptide, so their reaction
CC       forms an intrachain disulfide bond.
CC   -!- The 1-Cys Prxs conserve only the peroxidatic cysteine, so its
CC       regeneration involves direct interaction with a reductant molecule.
CC   -!- Thioredoxin-dependent peroxiredoxins are the most common.
CC   -!- They have been reported from archaea, bacteria, fungi, plants,
CC       and animals.
CC   -!- Formerly EC 1.11.1.15.
DR   P38013, AHP1_YEAST ;  Q96291, BAS1A_ARATH;  Q9C5R8, BAS1B_ARATH;
DR   Q96468, BAS1_HORVU ;  Q6ER94, BAS1_ORYSJ ;  P84729, BAS1_PINST ;
DR   O24364, BAS1_SPIOL ;  P80602, BAS1_WHEAT ;  P9WID8, BCPB_MYCTO ;
DR   P9WID9, BCPB_MYCTU ;  Q796Y8, BCP_BACSU  ;  Q9ZHF0, BCP_BUCAP  ;
DR   Q83CY8, BCP_COXBU  ;  P0AE54, BCP_ECO57  ;  P0AE53, BCP_ECOL6  ;
DR   P0AE52, BCP_ECOLI  ;  P44411, BCP_HAEIN  ;  Q9ZMU4, BCP_HELPJ  ;
DR   P55979, BCP_HELPY  ;  P9WIE0, BCP_MYCTO  ;  P9WIE1, BCP_MYCTU  ;
DR   P0AE55, BCP_SHIFL  ;  Q8P9V9, BCP_XANCP  ;  P06610, BTUE_ECOLI ;
DR   P19476, CR29_ENTH1 ;  P40553, DOT5_YEAST ;  O59858, GPX1_SCHPO ;
DR   P36014, GPX1_YEAST ;  P38143, GPX2_YEAST ;  Q59WD3, GPX3_CANAL ;
DR   P40581, GPX3_YEAST ;  O22448, GPX5_CHLRE ;  P56577, MALF2_MALFU;
DR   P56578, MALF3_MALFU;  Q9MB35, PERQ_SEDLI ;  Q6UBI3, PERQ_SUASA ;
DR   P14292, PMPA_CANBO ;  P14293, PMPB_CANBO ;  Q5E947, PRDX1_BOVIN;
DR   P0CB50, PRDX1_CHICK;  Q9JKY1, PRDX1_CRIGR;  Q6DV14, PRDX1_GEKJA;
DR   Q06830, PRDX1_HUMAN;  P35700, PRDX1_MOUSE;  Q6B4U9, PRDX1_MYOLU;
DR   Q63716, PRDX1_RAT  ;  Q9BGI3, PRDX2_BOVIN;  Q8K3U7, PRDX2_CRIGR;
DR   Q9V3P0, PRDX2_DROME;  P32119, PRDX2_HUMAN;  Q2PFZ3, PRDX2_MACFA;
DR   Q61171, PRDX2_MOUSE;  P52552, PRDX2_PIG  ;  Q5RC63, PRDX2_PONAB;
DR   P35704, PRDX2_RAT  ;  P35705, PRDX3_BOVIN;  Q9VEJ0, PRDX3_DROME;
DR   P30048, PRDX3_HUMAN;  P20108, PRDX3_MOUSE;  Q5REY3, PRDX3_PONAB;
DR   Q9Z0V6, PRDX3_RAT  ;  Q9BGI2, PRDX4_BOVIN;  P0CV91, PRDX4_CROAT;
DR   Q555L5, PRDX4_DICDI;  Q13162, PRDX4_HUMAN;  O08807, PRDX4_MOUSE;
DR   Q9Z0V5, PRDX4_RAT  ;  Q9BGI1, PRDX5_BOVIN;  Q9GLW7, PRDX5_CHLAE;
DR   P30044, PRDX5_HUMAN;  P86241, PRDX5_MESAU;  P99029, PRDX5_MOUSE;
DR   Q9GLW9, PRDX5_PAPHA;  Q9R063, PRDX5_RAT  ;  P83200, PRDX5_VULVU;
DR   Q54SE2, PRDXL_DICDI;  Q9NL98, PRDX_ASCSU ;  A0A0K3AUJ9, PRDX_CAEEL ;
DR   A0A2Z5VKM8, PRDX_CHAMQ ;  O43099, PRX5_ASPFU ;  Q5ASN8, PRX5_EMENI ;
DR   Q9Y8B8, PRX5_PENCI ;  Q9LU86, PRXQ_ARATH ;  Q75SY5, PRXQ_GENTR ;
DR   P0C5D4, PRXQ_ORYSI ;  P0C5D5, PRXQ_ORYSJ ;  Q6QPJ6, PRXQ_POPJC ;
DR   Q5S1S6, PRXQ_WHEAT ;  Q9L3Q5, PRXU_PEPAC ;  O94561, PRX_SCHPO  ;
DR   P0C5C8, REHYA_ORYSI;  P0C5C9, REHYA_ORYSJ;  P0C5D0, REHYB_ORYSI;
DR   P0C5D1, REHYB_ORYSJ;  O04005, REHY_ARATH ;  P52571, REHY_BROSE ;
DR   P52572, REHY_HORVU ;  A2SZW8, REHY_MAIZE ;  Q6E2Z6, REHY_MEDTR ;
DR   P52574, REHY_SYNRU ;  Q6W8Q2, REHY_WHEAT ;  P48822, TDX1_BRUMA ;
DR   Q21824, TDX1_CAEEL ;  Q17172, TDX2_BRUMA ;  Q8RCY5, TDXH1_CALS4;
DR   Q6L240, TDXH1_PICTO;  Q55060, TDXH1_SULME;  Q974S8, TDXH1_SULTO;
DR   Q9HKX0, TDXH1_THEAC;  Q8R844, TDXH2_CALS4;  Q6L140, TDXH2_PICTO;
DR   O33665, TDXH2_SULME;  Q96XS5, TDXH2_SULTO;  Q9HJL3, TDXH2_THEAC;
DR   Q9Y9L0, TDXH_AERPE ;  O67024, TDXH_AQUAE ;  O29969, TDXH_ARCFU ;
DR   Q8KBN8, TDXH_CHLTE ;  A2BJD9, TDXH_HYPBU ;  A8A9P0, TDXH_IGNH4 ;
DR   Q58146, TDXH_METJA ;  A4FWZ9, TDXH_METM5 ;  Q8PYP6, TDXH_METMA ;
DR   Q6LY19, TDXH_METMP ;  O26262, TDXH_METTH ;  Q57109, TDXH_METTM ;
DR   A6UPH7, TDXH_METVS ;  Q74NC6, TDXH_NANEQ ;  Q9UZV4, TDXH_PYRAB ;
DR   Q8U218, TDXH_PYRFU ;  O58966, TDXH_PYRHO ;  P95895, TDXH_SACS2 ;
DR   A3DKL1, TDXH_STAMF ;  Q5JF30, TDXH_THEKO ;  Q9WZR4, TDXH_THEMA ;
DR   A5IIX7, TDXH_THEP1 ;  Q979N7, TDXH_THEVO ;  Q73RS4, TDXH_TREDE ;
DR   Q90384, TDX_CYNPY  ;  Q8T6C4, TDX_ECHGR  ;  Q8SS85, TDX_ENCCU  ;
DR   P91883, TDX_FASHE  ;  Q91191, TDX_ONCMY  ;  Q26695, TDX_TRYBR  ;
DR   O74887, TPX1_SCHPO ;  O66780, TPX_AQUAE  ;  P80864, TPX_BACSU  ;
DR   Q9PPE0, TPX_CAMJE  ;  Q8KED5, TPX_CHLTE  ;  Q97E14, TPX_CLOAB  ;
DR   P81361, TPX_CLOPA  ;  Q8FQH8, TPX_COREF  ;  Q8NRG3, TPX_CORGL  ;
DR   P0A864, TPX_ECO57  ;  P0A863, TPX_ECOL6  ;  P0A862, TPX_ECOLI  ;
DR   Q57549, TPX_HAEIN  ;  Q9K813, TPX_HALH5  ;  Q9ZKE7, TPX_HELPJ  ;
DR   O25151, TPX_HELPY  ;  Q72NR4, TPX_LEPIC  ;  Q8F7T2, TPX_LEPIN  ;
DR   Q92BC5, TPX_LISIN  ;  Q71Z84, TPX_LISMF  ;  Q8Y6U8, TPX_LISMO  ;
DR   P66953, TPX_MYCBO  ;  P9WG34, TPX_MYCTO  ;  P9WG35, TPX_MYCTU  ;
DR   Q8EPB7, TPX_OCEIH  ;  P57880, TPX_PASMU  ;  P57668, TPX_PSEAE  ;
DR   Q8XVP0, TPX_RALN1  ;  Q8Z7A8, TPX_SALTI  ;  Q8ZP65, TPX_SALTY  ;
DR   P0A866, TPX_SHIDY  ;  P0A865, TPX_SHIFL  ;  Q5HF61, TPX_STAAC  ;
DR   P66954, TPX_STAAM  ;  P99146, TPX_STAAN  ;  Q6GFZ4, TPX_STAAR  ;
DR   Q6G8L4, TPX_STAAS  ;  Q8NW51, TPX_STAAW  ;  Q5HNJ2, TPX_STAEQ  ;
DR   Q8CS58, TPX_STAES  ;  Q4L754, TPX_STAHJ  ;  Q49YE4, TPX_STAS1  ;
DR   Q8E536, TPX_STRA3  ;  Q8DZH0, TPX_STRA5  ;  P42365, TPX_STREE  ;
DR   P42366, TPX_STRGN  ;  Q8DUK3, TPX_STRMU  ;  Q04JB8, TPX_STRP2  ;
DR   P31307, TPX_STRPA  ;  P0C2J8, TPX_STRPN  ;  P0A4M6, TPX_STRR6  ;
DR   P31308, TPX_STRSA  ;  A5F3A2, TPX_VIBC3  ;  P0C6P9, TPX_VIBCH  ;
DR   Q8ZE42, TPX_YERPE  ;  P0CU34, TSA1B_CANAL;  Q9Y7F0, TSA1_CANAL ;
DR   P34760, TSA1_YEAST ;  Q04120, TSA2_YEAST ;  Q55624, Y755_SYNY3 ;
DR   Q1XDL4, YCF42_NEOYE;  P51272, YCF42_PORPU;
//