ID 1.11.1.24 DE thioredoxin-dependent peroxiredoxin. AN thioredoxin peroxidase. CA a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]- CA disulfide + H2O. CC -!- Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant CC proteins. CC -!- They can be divided into three classes: typical 2-Cys, atypical 2-Cys CC and 1-Cys peroxiredoxins. CC -!- The peroxidase reaction comprises two steps centered around a redox- CC active cysteine called the peroxidatic cysteine. CC -!- All three peroxiredoxin classes have the first step in common, CC in which the peroxidatic cysteine attacks the peroxide substrate and CC is oxidized to S-hydroxycysteine (a sulfenic acid). CC -!- The second step of the peroxidase reaction, the regeneration of CC cysteine from S-hydroxycysteine, distinguishes the three CC peroxiredoxin classes. CC -!- For typical 2-Cys Prxs, in the second step, the peroxidatic CC S-hydroxycysteine from one subunit is attacked by the 'resolving' CC cysteine located in the C-terminus of the second subunit, to form an CC intersubunit disulfide bond, which is then reduced by one of several CC cell-specific thiol-containing reductants completing the catalytic CC cycle. CC -!- In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its CC resolving cysteine are in the same polypeptide, so their reaction CC forms an intrachain disulfide bond. CC -!- The 1-Cys Prxs conserve only the peroxidatic cysteine, so its CC regeneration involves direct interaction with a reductant molecule. CC -!- Thioredoxin-dependent peroxiredoxins are the most common. CC -!- They have been reported from archaea, bacteria, fungi, plants, CC and animals. CC -!- Formerly EC 1.11.1.15. DR G0S1P8, AHP1_CHATD ; P38013, AHP1_YEAST ; Q96291, BAS1A_ARATH; DR Q9C5R8, BAS1B_ARATH; Q96468, BAS1_HORVU ; Q6ER94, BAS1_ORYSJ ; DR P84729, BAS1_PINST ; O24364, BAS1_SPIOL ; P80602, BAS1_WHEAT ; DR P9WID8, BCPB_MYCTO ; P9WID9, BCPB_MYCTU ; Q796Y8, BCP_BACSU ; DR Q9ZHF0, BCP_BUCAP ; Q83CY8, BCP_COXBU ; P0AE54, BCP_ECO57 ; DR P0AE53, BCP_ECOL6 ; P0AE52, BCP_ECOLI ; P44411, BCP_HAEIN ; DR Q9ZMU4, BCP_HELPJ ; P55979, BCP_HELPY ; P9WIE0, BCP_MYCTO ; DR P9WIE1, BCP_MYCTU ; P0AE55, BCP_SHIFL ; Q8P9V9, BCP_XANCP ; DR P06610, BTUE_ECOLI ; P19476, CR29_ENTH1 ; P40553, DOT5_YEAST ; DR O59858, GPX1_SCHPO ; P36014, GPX1_YEAST ; P38143, GPX2_YEAST ; DR Q59WD3, GPX3_CANAL ; P40581, GPX3_YEAST ; O22448, GPX5_CHLRE ; DR P56577, MALF2_MALFU; P56578, MALF3_MALFU; Q9MB35, PERQ_SEDLI ; DR Q6UBI3, PERQ_SUASA ; P14292, PMPA_CANBO ; P14293, PMPB_CANBO ; DR Q5E947, PRDX1_BOVIN; P0CB50, PRDX1_CHICK; Q9JKY1, PRDX1_CRIGR; DR Q6DV14, PRDX1_GEKJA; Q06830, PRDX1_HUMAN; P35700, PRDX1_MOUSE; DR Q6B4U9, PRDX1_MYOLU; Q63716, PRDX1_RAT ; Q9BGI3, PRDX2_BOVIN; DR Q8K3U7, PRDX2_CRIGR; Q9V3P0, PRDX2_DROME; P32119, PRDX2_HUMAN; DR Q2PFZ3, PRDX2_MACFA; Q61171, PRDX2_MOUSE; P52552, PRDX2_PIG ; DR Q5RC63, PRDX2_PONAB; P35704, PRDX2_RAT ; P35705, PRDX3_BOVIN; DR Q9VEJ0, PRDX3_DROME; P30048, PRDX3_HUMAN; P20108, PRDX3_MOUSE; DR Q5REY3, PRDX3_PONAB; Q9Z0V6, PRDX3_RAT ; Q9BGI2, PRDX4_BOVIN; DR P0CV91, PRDX4_CROAT; Q555L5, PRDX4_DICDI; Q13162, PRDX4_HUMAN; DR O08807, PRDX4_MOUSE; Q9Z0V5, PRDX4_RAT ; Q9BGI1, PRDX5_BOVIN; DR Q9GLW7, PRDX5_CHLAE; P30044, PRDX5_HUMAN; P86241, PRDX5_MESAU; DR P99029, PRDX5_MOUSE; Q9GLW9, PRDX5_PAPHA; Q9R063, PRDX5_RAT ; DR P83200, PRDX5_VULVU; Q54SE2, PRDXL_DICDI; Q9NL98, PRDX_ASCSU ; DR A0A0K3AUJ9, PRDX_CAEEL ; A0A2Z5VKM8, PRDX_CHAMQ ; O43099, PRX5_ASPFU ; DR Q5ASN8, PRX5_EMENI ; Q9Y8B8, PRX5_PENCI ; Q9LU86, PRXQ_ARATH ; DR Q75SY5, PRXQ_GENTR ; P0C5D4, PRXQ_ORYSI ; P0C5D5, PRXQ_ORYSJ ; DR Q6QPJ6, PRXQ_POPJC ; Q5S1S6, PRXQ_WHEAT ; Q9L3Q5, PRXU_PEPAC ; DR O94561, PRX_SCHPO ; P0C5C8, REHYA_ORYSI; P0C5C9, REHYA_ORYSJ; DR P0C5D0, REHYB_ORYSI; P0C5D1, REHYB_ORYSJ; O04005, REHY_ARATH ; DR P52571, REHY_BROSE ; P52572, REHY_HORVU ; A2SZW8, REHY_MAIZE ; DR Q6E2Z6, REHY_MEDTR ; P52574, REHY_SYNRU ; Q6W8Q2, REHY_WHEAT ; DR P48822, TDX1_BRUMA ; Q21824, TDX1_CAEEL ; Q17172, TDX2_BRUMA ; DR Q8RCY5, TDXH1_CALS4; Q6L240, TDXH1_PICTO; Q55060, TDXH1_SULME; DR Q974S8, TDXH1_SULTO; Q9HKX0, TDXH1_THEAC; Q8R844, TDXH2_CALS4; DR Q6L140, TDXH2_PICTO; O33665, TDXH2_SULME; Q96XS5, TDXH2_SULTO; DR Q9HJL3, TDXH2_THEAC; Q9Y9L0, TDXH_AERPE ; O67024, TDXH_AQUAE ; DR O29969, TDXH_ARCFU ; Q8KBN8, TDXH_CHLTE ; A2BJD9, TDXH_HYPBU ; DR A8A9P0, TDXH_IGNH4 ; Q58146, TDXH_METJA ; A4FWZ9, TDXH_METM5 ; DR Q8PYP6, TDXH_METMA ; Q6LY19, TDXH_METMP ; O26262, TDXH_METTH ; DR Q57109, TDXH_METTM ; A6UPH7, TDXH_METVS ; Q74NC6, TDXH_NANEQ ; DR Q9UZV4, TDXH_PYRAB ; Q8U218, TDXH_PYRFU ; O58966, TDXH_PYRHO ; DR P95895, TDXH_SACS2 ; A3DKL1, TDXH_STAMF ; Q5JF30, TDXH_THEKO ; DR Q9WZR4, TDXH_THEMA ; A5IIX7, TDXH_THEP1 ; Q979N7, TDXH_THEVO ; DR Q73RS4, TDXH_TREDE ; Q90384, TDX_CYNPY ; Q8T6C4, TDX_ECHGR ; DR Q8SS85, TDX_ENCCU ; P91883, TDX_FASHE ; Q91191, TDX_ONCMY ; DR Q26695, TDX_TRYBR ; O74887, TPX1_SCHPO ; O66780, TPX_AQUAE ; DR P80864, TPX_BACSU ; Q9PPE0, TPX_CAMJE ; Q8KED5, TPX_CHLTE ; DR Q97E14, TPX_CLOAB ; P81361, TPX_CLOPA ; Q8FQH8, TPX_COREF ; DR Q8NRG3, TPX_CORGL ; P0A864, TPX_ECO57 ; P0A863, TPX_ECOL6 ; DR P0A862, TPX_ECOLI ; Q57549, TPX_HAEIN ; Q9K813, TPX_HALH5 ; DR Q9ZKE7, TPX_HELPJ ; O25151, TPX_HELPY ; Q72NR4, TPX_LEPIC ; DR Q8F7T2, TPX_LEPIN ; Q92BC5, TPX_LISIN ; Q71Z84, TPX_LISMF ; DR Q8Y6U8, TPX_LISMO ; P66953, TPX_MYCBO ; P9WG34, TPX_MYCTO ; DR P9WG35, TPX_MYCTU ; Q8EPB7, TPX_OCEIH ; P57880, TPX_PASMU ; DR P57668, TPX_PSEAE ; Q8XVP0, TPX_RALN1 ; Q8Z7A8, TPX_SALTI ; DR Q8ZP65, TPX_SALTY ; P0A866, TPX_SHIDY ; P0A865, TPX_SHIFL ; DR Q5HF61, TPX_STAAC ; P66954, TPX_STAAM ; P99146, TPX_STAAN ; DR Q6GFZ4, TPX_STAAR ; Q6G8L4, TPX_STAAS ; Q8NW51, TPX_STAAW ; DR Q5HNJ2, TPX_STAEQ ; Q8CS58, TPX_STAES ; Q4L754, TPX_STAHJ ; DR Q49YE4, TPX_STAS1 ; Q8E536, TPX_STRA3 ; Q8DZH0, TPX_STRA5 ; DR P42365, TPX_STREE ; P42366, TPX_STRGN ; Q8DUK3, TPX_STRMU ; DR Q04JB8, TPX_STRP2 ; P31307, TPX_STRPA ; P0C2J8, TPX_STRPN ; DR P0A4M6, TPX_STRR6 ; P31308, TPX_STRSA ; A5F3A2, TPX_VIBC3 ; DR P0C6P9, TPX_VIBCH ; Q8ZE42, TPX_YERPE ; P0CU34, TSA1B_CANAL; DR Q9Y7F0, TSA1_CANAL ; P34760, TSA1_YEAST ; Q04120, TSA2_YEAST ; DR Q55624, Y755_SYNY3 ; P51272, YCF42_PORPU; Q1XDL4, YCF42_PYRYE; //