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ENZYME entry: EC 1.11.1.25

Accepted Name
Glutaredoxin-dependent peroxiredoxin.
Reaction catalysed
Glutaredoxin + ROOH <=> glutaredoxin disulfide + H(2)O + ROH
Comment(s)
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins .
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule.
  • Glutaredoxin-dependent peroxiredoxins have been reported from bacteria, fungi, plants, and animals.
  • These enzymes are often able to use an alternative reductant such as thioredoxin or glutathione.
  • Formerly EC 1.11.1.15.
Cross-references
BRENDA1.11.1.25
EC2PDB1.11.1.25
ExplorEnz1.11.1.25
PRIAM enzyme-specific profiles1.11.1.25
KEGG Ligand Database for Enzyme Nomenclature1.11.1.25
IUBMB Enzyme Nomenclature1.11.1.25
IntEnz1.11.1.25
MEDLINEFind literature relating to 1.11.1.25
MetaCyc1.11.1.25
UniProtKB/Swiss-Prot
Q69TY4, PR2E1_ORYSJ;  Q7F8S5, PR2E2_ORYSJ;  P34227, PRX1_YEAST;  
Q7G959, PRX2A_ARATH;  Q9XEX2, PRX2B_ARATH;  Q9SRZ4, PRX2C_ARATH;  
Q9FR35, PRX2C_ORYSJ;  O22711, PRX2D_ARATH;  Q949U7, PRX2E_ARATH;  
Q9M7T0, PRX2F_ARATH;  Q9SDD6, PRX2F_ORYSJ;  A9PCL4, PRX2_POPTR;  

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