Accepted Name |
glutaredoxin-dependent peroxiredoxin
|
Reaction catalysed |
[glutaredoxin]-dithiol + a hydroperoxide <=> [glutaredoxin]-disulfide + an alcohol + H2O |
Comment(s) |
- Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant
proteins.
- They can be divided into three classes: typical 2-Cys, atypical 2-Cys
and 1-Cys peroxiredoxins .
- The peroxidase reaction comprises two steps centered around a redox-
active cysteine called the peroxidatic cysteine.
- All three peroxiredoxin classes have the first step in common,
in which the peroxidatic cysteine attacks the peroxide substrate and
is oxidized to S-hydroxycysteine (a sulfenic acid).
- The second step of the peroxidase reaction, the regeneration of
cysteine from S-hydroxycysteine, distinguishes the three
peroxiredoxin classes.
- For typical 2-Cys Prxs, in the second step, the peroxidatic
S-hydroxycysteine from one subunit is attacked by the 'resolving'
cysteine located in the C-terminus of the second subunit, to form an
intersubunit disulfide bond, which is then reduced by one of several
cell-specific thiol-containing reductants completing the catalytic
cycle.
- In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its
resolving cysteine are in the same polypeptide, so their reaction
forms an intrachain disulfide bond.
- To recycle the disulfide, known atypical 2-Cys Prxs appear to use
thioredoxin as an electron donor.
- The 1-Cys Prxs conserve only the peroxidatic cysteine, so its
regeneration involves direct interaction with a reductant molecule.
- Glutaredoxin-dependent peroxiredoxins have been reported from
bacteria, fungi, plants, and animals.
- These enzymes are often able to use an alternative reductant such as
thioredoxin or glutathione.
- Formerly EC 1.11.1.15.
|
Cross-references |
BRENDA | 1.11.1.25 |
EC2PDB | 1.11.1.25 |
ExplorEnz | 1.11.1.25 |
PRIAM enzyme-specific profiles | 1.11.1.25 |
KEGG Ligand Database for Enzyme Nomenclature | 1.11.1.25 |
IUBMB Enzyme Nomenclature | 1.11.1.25 |
IntEnz | 1.11.1.25 |
MEDLINE | Find literature relating to 1.11.1.25 |
MetaCyc | 1.11.1.25 |
Rhea expert-curated reactions | 1.11.1.25 |
UniProtKB/Swiss-Prot |
Q69TY4, PR2E1_ORYSJ | Q7F8S5, PR2E2_ORYSJ | P34227, PRX1_YEAST |
Q7G959, PRX2A_ARATH | Q9XEX2, PRX2B_ARATH | Q9SRZ4, PRX2C_ARATH |
Q9FR35, PRX2C_ORYSJ | O22711, PRX2D_ARATH | Q949U7, PRX2E_ARATH |
Q9M7T0, PRX2F_ARATH | Q9SDD6, PRX2F_ORYSJ | A9PCL4, PRX2_POPTR |
|
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