ID   1.11.1.8
DE   iodide peroxidase.
AN   iodinase.
AN   thyroid peroxidase.
AN   thyroperoxidase.
AN   TPO.
CA   (1) 2 iodide + H2O2 + 2 H(+) = diiodine + 2 H2O.
CA   (2) [thyroglobulin]-L-tyrosine + iodide + H2O2 + H(+) = [thyroglobulin]-
CA   3-iodo-L-tyrosine + 2 H2O.
CA   (3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H(+) =
CA   [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.
CA   (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-
CA   thyroxine + [thyroglobulin]-dehydroalanine + 2 H2O.
CA   (5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-
CA   tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine +
CA   [thyroglobulin]-dehydroalanine + 2 H2O.
CC   -!- Thyroid peroxidase catalyzes the biosynthesis of the thyroid hormones
CC       L-thyroxine and triiodo-L-thyronine.
CC   -!- It catalyzes both the iodination of tyrosine residues in
CC       thyroglobulin (forming mono- and di-iodinated forms) and their
CC       coupling to form either L-thyroxine or triiodo-L-thyronine.
DR   Q8HYB7, PERT_CANLF ;  P07202, PERT_HUMAN ;  P35419, PERT_MOUSE ;
DR   P09933, PERT_PIG   ;  P14650, PERT_RAT   ;
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