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ENZYME entry: EC 1.12.2.1

Accepted Name
cytochrome-c3 hydrogenase.
Alternative Name(s)
cytochrome c3 reductase.
cytochrome hydrogenase.
H2:ferricytochrome c3 oxidoreductase.
Reaction catalysed
2 Fe(III)-[cytochrome c3] + H2 <=> 2 Fe(II)-[cytochrome c3] + 2 H(+)
Comment(s)
  • Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases).
  • Methylene blue and other acceptors can also be reduced.
Cross-references
BRENDA1.12.2.1
EC2PDB1.12.2.1
ExplorEnz1.12.2.1
PRIAM enzyme-specific profiles1.12.2.1
KEGG Ligand Database for Enzyme Nomenclature1.12.2.1
IUBMB Enzyme Nomenclature1.12.2.1
IntEnz1.12.2.1
MEDLINEFind literature relating to 1.12.2.1
MetaCyc1.12.2.1
Rhea expert-curated reactions1.12.2.1
UniProtKB/Swiss-Prot
P80509, HC3L_ACIFR;  P80510, HC3S_ACIFR;  P21852, PHNL_DESVM;  
P12944, PHNL_MEGGA;  P18188, PHNL_SOLFR;  Q06173, PHNS1_DESVH;  
P61429, PHNS2_DESVH;  P13061, PHNS_DESDA;  P13062, PHNS_DESMU;  
P21853, PHNS_DESVM;  P12943, PHNS_MEGGA;  P18187, PHNS_SOLFR;  

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