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ENZYME entry: EC 1.12.98.1

Accepted Name
Coenzyme F420 hydrogenase.
Alternative Name(s)
8-hydroxy-5-deazaflavin-reducing hydrogenase.
Coenzyme F420-dependent hydrogenase.
F420-reducing hydrogenase.
Reaction catalysed
H(2) + oxidized coenzyme F420 <=> reduced coenzyme F420
Cofactor(s)
FAD; Fe cation; Ni(2+).
Comment(s)
  • The enzyme from some sources contains selenocysteine.
  • The enzyme also reduces the riboflavin analog of F420, flavins and methylviologen, but to a lesser extent.
  • The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
  • Formerly EC 1.12.99.1.
Cross-references
BRENDA1.12.98.1
EC2PDB1.12.98.1
ExplorEnz1.12.98.1
PRIAM enzyme-specific profiles1.12.98.1
KEGG Ligand Database for Enzyme Nomenclature1.12.98.1
IUBMB Enzyme Nomenclature1.12.98.1
IntEnz1.12.98.1
MEDLINEFind literature relating to 1.12.98.1
MetaCyc1.12.98.1
Rhea expert-curated reactions1.12.98.1
UniProtKB/Swiss-Prot
P80489, FRHA_METBF;  Q60338, FRHA_METJA;  P19496, FRHA_METTH;  
Q00390, FRHA_METVO;  P80490, FRHB_METBF;  Q60341, FRHB_METJA;  
P19499, FRHB_METTH;  Q00391, FRHB_METVO;  P80491, FRHG_METBF;  
Q60340, FRHG_METJA;  P19498, FRHG_METTH;  Q00393, FRHG_METVO;  

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