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ENZYME entry: EC 1.13.11.33

Accepted Name
Arachidonate 15-lipoxygenase.
Alternative Name(s)
15-lipoxygenase.
Arachidonate omega(6) lipoxygenase.
Reaction catalysed
Arachidonate + O(2) <=> (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
Cofactor(s)
Fe cation.
Comment(s)
The product is rapidly converted to the corresponding 15S-hydroxy compound.
Cross-references
PROSITEPDOC00077
BRENDA1.13.11.33
EC2PDB1.13.11.33
ExplorEnz1.13.11.33
PRIAM enzyme-specific profiles1.13.11.33
KEGG Ligand Database for Enzyme Nomenclature1.13.11.33
IUBMB Enzyme Nomenclature1.13.11.33
IntEnz1.13.11.33
MEDLINEFind literature relating to 1.13.11.33
MetaCyc1.13.11.33
Rhea expert-curated reactions1.13.11.33
UniProtKB/Swiss-Prot
P18054, LOX12_HUMAN;  P39655, LOX12_MOUSE;  F1LQ70, LOX12_RAT;  
P27479, LOX15_BOVIN;  P16050, LOX15_HUMAN;  P39654, LOX15_MOUSE;  
P16469, LOX15_PIG;  Q5RBE8, LOX15_PONAB;  P12530, LOX15_RABIT;  
Q02759, LOX15_RAT;  Q9I4G8, LOXA_PSEAE;  O15296, LX15B_HUMAN;  
Q8K4F2, LX15B_RAT;  

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