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ENZYME entry: EC 1.13.11.39

Accepted Name
Biphenyl-2,3-diol 1,2-dioxygenase.
Alternative Name(s)
2,3-dihydroxybiphenyl dioxygenase.
Reaction catalysed
Biphenyl-2,3-diol + O(2) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
Cofactor(s)
Mn(2+) or Fe cation.
Comment(s)
  • This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyzes the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56.
  • The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently.
  • The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol.
  • The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2- dihydroxydibenzofuran and 1,2-dihydroxynaphthalene.
  • The enzyme is strongly inhibited by the substrate.
  • Not identical with EC 1.13.11.2.
Cross-references
PROSITEPDOC00078
BRENDA1.13.11.39
EC2PDB1.13.11.39
ExplorEnz1.13.11.39
PRIAM enzyme-specific profiles1.13.11.39
KEGG Ligand Database for Enzyme Nomenclature1.13.11.39
IUBMB Enzyme Nomenclature1.13.11.39
IntEnz1.13.11.39
MEDLINEFind literature relating to 1.13.11.39
MetaCyc1.13.11.39
Rhea expert-curated reactions1.13.11.39
UniProtKB/Swiss-Prot
P47231, BPHC1_RHOGO;  P47232, BPHC2_RHOGO;  P47233, BPHC3_RHOGO;  
Q8GR45, BPHC_BACPJ;  P47228, BPHC_PARXL;  P08695, BPHC_PSEFK;  
P17297, BPHC_PSES1;  P11122, BPHC_SPHPI;  

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