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ENZYME entry: EC 1.13.11.45

Accepted Name
Linoleate 11-lipoxygenase.
Alternative Name(s)
Linoleate dioxygenase.
Manganese lipoxygenase.
Reaction catalysed
Linoleate + O(2) <=> (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate
Comment(s)
  • The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13- hydroperoxyoctadeca-9,11-dienoate.
  • The enzyme from the fungus Gaeumannomyces graminis requires Mn(2+).
  • It also acts on alpha-linolenate, whereas gamma-linolenate is a poor substrate.
  • Oleate and arachidonate are not substrates.
Cross-references
BRENDA1.13.11.45
EC2PDB1.13.11.45
ExplorEnz1.13.11.45
PRIAM enzyme-specific profiles1.13.11.45
KEGG Ligand Database for Enzyme Nomenclature1.13.11.45
IUBMB Enzyme Nomenclature1.13.11.45
IntEnz1.13.11.45
MEDLINEFind literature relating to 1.13.11.45
MetaCyc1.13.11.45
Rhea expert-curated reactions1.13.11.45
UniProtKB/Swiss-Prot
T0JRM4, MNLOX_COLGC;  F9FRH4, MNLOX_FUSOF;  Q8X151, MNLOX_GAEAV;  
Q8X150, MNLOX_GAETR;  G4NAP4, MNLOX_MAGO7;  P0CT92, MNLOX_NAKOS;  

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