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ENZYME

ENZYME entry: EC 1.13.11.45

Accepted Name
linoleate 11-lipoxygenase
Alternative Name(s)
linoleate dioxygenase
manganese lipoxygenase
Reaction catalysed
(9Z,12Z)-octadecadienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate
Comment(s)
  • The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13- hydroperoxyoctadeca-9,11-dienoate.
  • The enzyme from the fungus Gaeumannomyces graminis requires Mn(2+).
  • It also acts on alpha-linolenate, whereas gamma-linolenate is a poor substrate.
  • Oleate and arachidonate are not substrates.
Cross-references
BRENDA1.13.11.45
EC2PDB1.13.11.45
ExplorEnz1.13.11.45
PRIAM enzyme-specific profiles1.13.11.45
KEGG Ligand Database for Enzyme Nomenclature1.13.11.45
IUBMB Enzyme Nomenclature1.13.11.45
IntEnz1.13.11.45
MEDLINEFind literature relating to 1.13.11.45
MetaCyc1.13.11.45
Rhea expert-curated reactions1.13.11.45
UniProtKB/Swiss-Prot
T0JRM4, MNLOX_COLGCF9FRH4, MNLOX_FUSOFQ8X151, MNLOX_GAEAV
Q8X150, MNLOX_GAETRG4NAP4, MNLOX_MAGO7P0CT92, MNLOX_NAKOS

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