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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.13.11.51

Accepted Name
9-cis-epoxycarotenoid dioxygenase.
Alternative Name(s)
NCED.
Nine-cis-epoxycarotenoid dioxygenase.
VP14.
Reaction catalysed
  • A 9-cis-epoxycarotenoid + O(2) <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
  • 9-cis-violaxanthin + O(2) <=> 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
  • 9'-cis-neoxanthin + O(2) <=> 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
Cofactor(s)
Fe cation.
Comment(s)
  • Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all- trans isomers.
  • In vitro, it will cleave 9-cis-zeaxanthin.
  • Catalyzes the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress.
  • The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288, EC 1.2.3.14 and EC 1.14.13.93.
Cross-references
BRENDA1.13.11.51
EC2PDB1.13.11.51
ExplorEnz1.13.11.51
PRIAM enzyme-specific profiles1.13.11.51
KEGG Ligand Database for Enzyme Nomenclature1.13.11.51
IUBMB Enzyme Nomenclature1.13.11.51
IntEnz1.13.11.51
MEDLINEFind literature relating to 1.13.11.51
MetaCyc1.13.11.51
UniProtKB/Swiss-Prot
O24592, NCED1_MAIZE;  Q6YVJ0, NCED1_ORYSJ;  Q9M6E8, NCED1_PHAVU;  
O24023, NCED1_SOLLC;  O49505, NCED2_ARATH;  Q5MBR6, NCED2_ORYSJ;  
K4CJJ1, NCED2_SOLLC;  Q9LRR7, NCED3_ARATH;  Q5MBR5, NCED3_ORYSJ;  
Q69NX5, NCED4_ORYSJ;  Q9C6Z1, NCED5_ARATH;  Q5MBR3, NCED5_ORYSJ;  
Q9LRM7, NCED6_ARATH;  Q9M9F5, NCED9_ARATH;  C3VEQ3, NCED_ONCHC;  

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