ID   1.13.11.60
DE   linoleate 8R-lipoxygenase.
AN   5,8-linoleate diol synthase (bifunctional enzyme).
AN   7,8-linoleate diol synthase (bifunctional enzyme).
CA   (9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-
CA   dienoate.
CC   -!- The bifunctional enzyme from Aspergillus nidulans uses different heme
CC       domains to catalyze two separate reactions.
CC   -!- Linoleic acid is oxidized within the N-terminal heme peroxidase
CC       domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is
CC       subsequently isomerized by the C-terminal P450 heme thiolate domain
CC       to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf.
CC       EC 5.4.4.5).
CC   -!- The bifunctional enzyme from Gaeumannomyces graminis also catalyzes
CC       the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-
CC       9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-
CC       5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6).
CC   -!- Formerly EC 1.13.11.44.
DR   Q9UUS2, LIDS_GAEGR ;  G4N4J5, LIDS_PYRO7 ;  B0Y6R2, PPOA_ASPFC ;
DR   Q4WPX2, PPOA_ASPFU ;  Q6RET3, PPOA_EMEND ;  G5EB19, PPOA_EMENI ;
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