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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Beta-carotene 15,15'-dioxygenase.
Alternative Name(s)
Beta-carotene 15,15'-monooxygenase.
Carotene 15,15'-dioxygenase.
Carotene dioxygenase.
Reaction catalysed
Beta-carotene + O(2) <=> 2 all-trans-retinal
Fe cation.
  • The enzyme cleaves beta-carotene symmetrically, producing two molecules of all-trans-retinal.
  • Both atoms of the oxygen molecule are incorporated into the products.
  • The enzyme can also process beta-cryptoxanthin, 8'-apo-beta- carotenal, 4'-apo-beta-carotenal, alpha-carotene and gamma-carotene in decreasing order.
  • The presence of at least one unsubstituted beta-ionone ring in a substrate greater than C(30) is mandatory.
  • A prokaryotic enzyme has been reported from the uncultured marine bacterium 66A03, where it is involved in the proteorhodopsin system, which uses retinal as its chromophore.
  • Formerly EC 1.13.11.n2.
PRIAM enzyme-specific profiles1.13.11.63
KEGG Ligand Database for Enzyme Nomenclature1.13.11.63
IUBMB Enzyme Nomenclature1.13.11.63
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-