A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 188.8.131.52
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|FMNH(2) + NADH + O(2) <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD(+) + other product(s)|
- The enzyme catalyzes a complex oxygen-dependent conversion of reduced
flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower
ligand of vitamin B12.
- This conversion involves many sequential steps in two distinct
stages, and an alloxan intermediate that acts as a proton donor,
a proton acceptor, and a hydride acceptor.
- The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the
ribityl group of FMNH(2) and 2-H from the ribityl 1'-pro-S hydrogen.
- While D-erythrose 4-phosphate has been shown to be one of the
byproducts, the nature of the other product(s) has not been verified
- Formerly EC 184.108.40.206.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
entries corresponding to 1.13.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-