ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.13.12.15

Accepted Name
3,4-dihydroxyphenylalanine oxidative deaminase.
Alternative Name(s)
DOPA oxidative deaminase.
DOPAODA.
Oxidative deaminase.
Reaction catalysed
2 L-dopa + O(2) <=> 2 3,4-dihydroxyphenylpyruvate + 2 NH(3)
Comment(s)
One of the three enzymes involved in L-dopa (3,4- dihydroxyphenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought), the other two being EC 4.3.1.22 and EC 2.6.1.49. In addition to DOPA, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. Inhibited by NADH and 2-oxoglutarate.
Cross-references
BRENDA	1.13.12.15
EC2PDB	1.13.12.15
ExplorEnz	1.13.12.15
PRIAM enzyme-specific profiles	1.13.12.15
KEGG Ligand Database for Enzyme Nomenclature	1.13.12.15
IUBMB Enzyme Nomenclature	1.13.12.15
IntEnz	1.13.12.15
MEDLINE	Find literature relating to 1.13.12.15
MetaCyc	1.13.12.15

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