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ENZYME

ENZYME entry: EC 1.13.12.16

PURL: https://purl.expasy.org/enzyme/EC/1.13.12.16
Accepted Name
nitronate monooxygenase
Alternative Name(s)
2-nitropropane dioxygenase
2-NPD
nitroalkane oxidase
NMO
Reaction catalysed
ethylnitronate + O2 = chemical entity + acetaldehyde + nitrite + H(+)
Comment(s)
  • Previously classified as EC 1.13.11.32, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms.
  • The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor.
  • Neither hydrogen peroxide nor superoxide were detected during enzyme turnover.
  • Active toward linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, toward propyl-2-nitronate.
  • The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity.
  • Formerly EC 1.13.11.32.
Cross-references
BRENDA1.13.12.16
EC2PDB1.13.12.16
ExplorEnz1.13.12.16
KEGG Ligand Database for Enzyme Nomenclature1.13.12.16
IUBMB Enzyme Nomenclature1.13.12.16
MEDLINEFind literature relating to 1.13.12.16
MetaCyc1.13.12.16
Rhea expert-curated reactions1.13.12.16
UniProtKB/Swiss-Prot
P47177, 2NDP_YEASTQ12723, 2NPD_CYBMRQ01284, 2NPD_NEUCR

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