ENZYME entry: EC 1.13.12.16
Accepted Name |
Nitronate monooxygenase.
|
Alternative Name(s) |
2-nitropropane dioxygenase. |
2-NPD. |
Nitroalkane oxidase. |
NMO. |
Reaction catalysed |
Ethylnitronate + O(2) <=> acetaldehyde + nitrite + other products |
Cofactor(s) |
FMN.
|
Comment(s) |
- Previously classified as EC 1.13.11.32, but it is now recognized that
this was the result of the slow ionization of nitroalkanes to their
nitronate (anionic) forms.
- The enzymes from the fungus Neurospora crassa and the yeast
Williopsis saturnus var. mrakii (formerly classified as Hansenula
mrakii) contain non-covalently bound FMN as the cofactor.
- Neither hydrogen peroxide nor superoxide were detected during enzyme
turnover.
- Active toward linear alkyl nitronates of lengths between 2 and 6
carbon atoms and, with lower activity, toward propyl-2-nitronate.
- The enzyme from N.crassa can also utilize neutral nitroalkanes,
but with lower activity.
- Formerly EC 1.13.11.32.
|
Cross-references |
BRENDA | 1.13.12.16 |
EC2PDB | 1.13.12.16 |
ExplorEnz | 1.13.12.16 |
PRIAM enzyme-specific profiles | 1.13.12.16 |
KEGG Ligand Database for Enzyme Nomenclature | 1.13.12.16 |
IUBMB Enzyme Nomenclature | 1.13.12.16 |
IntEnz | 1.13.12.16 |
MEDLINE | Find literature relating to 1.13.12.16 |
MetaCyc | 1.13.12.16 |
UniProtKB/Swiss-Prot |
|
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