ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.13.12.16

Accepted Name

Nitronate monooxygenase.

Alternative Name(s)

2-nitropropane dioxygenase.

2-NPD.

Nitroalkane oxidase.

NMO.

Reaction catalysed

Ethylnitronate + O(2) <=> acetaldehyde + nitrite + other products

Cofactor(s)

FMN.

Comment(s)

Previously classified as EC 1.13.11.32, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms.
The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor.
Neither hydrogen peroxide nor superoxide were detected during enzyme turnover.
Active toward linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, toward propyl-2-nitronate.
The enzyme from N.crassa can also utilize neutral nitroalkanes, but with lower activity.
Formerly EC 1.13.11.32.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature