A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 184.108.40.206
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|Photinus pyralis luciferase.|
|Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing).|
|D-firefly luciferin + O(2) + ATP <=> firefly oxyluciferin + CO(2) + AMP + diphosphate + light|
- The enzyme, which is found in fireflies (Lampyridae), is responsible
for their biolouminescence.
- The reaction begins with the formation of an acid anhydride between
the carboxylic group of D-firefly luciferin and AMP, with the release
- An oxygenation follows, with release of the AMP group and formation
of a very short-lived peroxide that cyclizes into a dioxetanone
structure, which collapses, releasing a CO(2) molecule.
- The spontaneous breakdown of the dioxetanone (rather than the
hydrolysis of the adenylate) releases the energy (about 50 kcal/mole)
that is necessary to generate the excited state of oxyluciferin.
- The excited luciferin then emits a photon, returning to its ground
- The enzyme has a secondary acyl-CoA ligase activity when acting on
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
entries corresponding to 1.13.12.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-