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ENZYME entry: EC 1.13.99.3

Accepted Name
Tryptophan 2'-dioxygenase.
Alternative Name(s)
Indole-3-alkane alpha-hydroxylase.
Tryptophan side-chain alpha,beta-oxidase.
Tryptophan side-chain oxidase.
TSO.
Reaction catalysed
L-tryptophan + O(2) <=> (indol-3-yl)glycolaldehyde + CO(2) + NH(3)
Cofactor(s)
Heme.
Comment(s)
  • Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position.
  • Best substrates are L-tryptophan and 5-hydroxy-L-tryptophan.
Cross-references
BRENDA1.13.99.3
EC2PDB1.13.99.3
ExplorEnz1.13.99.3
PRIAM enzyme-specific profiles1.13.99.3
KEGG Ligand Database for Enzyme Nomenclature1.13.99.3
IUBMB Enzyme Nomenclature1.13.99.3
IntEnz1.13.99.3
MEDLINEFind literature relating to 1.13.99.3
MetaCyc1.13.99.3
Rhea expert-curated reactions1.13.99.3

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