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ENZYME

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ENZYME entry: EC 1.14.11.2

Accepted Name
procollagen-proline 4-dioxygenase
Alternative Name(s)
procollagen-proline,2-oxoglutarate-4-dioxygenase
procollagen-proline dioxygenase
proline,2-oxoglutarate 4-dioxygenase
proline hydroxylase
prolyl 4-hydroxylase
prolyl hydroxylase
protocollagen hydroxylase
Reaction catalysed
2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]
Comment(s)
  • The enzyme, which is located within the lumen of the endoplasmic reticulum, catalyzes the 4-hydroxylation of prolines in -X-Pro-Gly- sequences.
  • The 4-hydroxyproline residues are essential for the formation of the collagen triple helix.
  • The enzyme forms a complex with protein disulfide isomerase and acts not only on procollagen but also on more than 15 other proteins that have collagen-like domains.
Cross-references
BRENDA1.14.11.2
EC2PDB1.14.11.2
ExplorEnz1.14.11.2
PRIAM enzyme-specific profiles1.14.11.2
KEGG Ligand Database for Enzyme Nomenclature1.14.11.2
IUBMB Enzyme Nomenclature1.14.11.2
IntEnz1.14.11.2
MEDLINEFind literature relating to 1.14.11.2
MetaCyc1.14.11.2
Rhea expert-curated reactions1.14.11.2
UniProtKB/Swiss-Prot
F4JZ24, P4H10_ARATHQ9SZT0, P4H11_ARATHQ8GXT7, P4H12_ARATH
F4ILF8, P4H13_ARATHQ9ZW86, P4H1_ARATHF4JAU3, P4H2_ARATH
Q9LN20, P4H3_ARATHQ8LAN3, P4H4_ARATHQ24JN5, P4H5_ARATH
F4J0A8, P4H6_ARATHQ8L970, P4H7_ARATHF4JNU8, P4H8_ARATH
Q8VZJ7, P4H9_ARATHQ1RMU3, P4HA1_BOVINQ10576, P4HA1_CAEEL
P16924, P4HA1_CHICKP13674, P4HA1_HUMANQ60715, P4HA1_MOUSE
Q5RAG8, P4HA1_PONABP54001, P4HA1_RATQ20065, P4HA2_CAEEL
Q5ZLK5, P4HA2_CHICKO15460, P4HA2_HUMANQ60716, P4HA2_MOUSE
Q75UG4, P4HA3_BOVINQ7Z4N8, P4HA3_HUMANQ6W3F0, P4HA3_MOUSE
Q6W3E9, P4HA3_RATQ5UP57, P4H_MIMIV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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