ID 1.14.11.21 DE clavaminate synthase. AN clavaminic acid synthase. CA (1) 2-oxoglutarate + deoxyamidinoproclavaminate + O2 = CA amidinoproclavaminate + CO2 + succinate. CA (2) 2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + CA H2O + succinate. CA (3) 2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + CA succinate. CC -!- Catalyzes three separate oxidative reactions in the pathway for the CC biosythesis of the beta-lactamase inhibitor clavulanate in CC Streptomyces clavuligerus. CC -!- The first step (hydroxylation) is separated from the latter two CC (oxidative cyclization and desaturation) by the action of CC EC 3.5.3.22. CC -!- The three reactions are all catalyzed at the same nonheme iron site. DR Q05581, CAS1_STRCL ; Q05582, CAS2_STRCL ; //