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ENZYME

ENZYME entry: EC 1.14.11.26

Accepted Name
deacetoxycephalosporin-C hydroxylase
Alternative Name(s)
3'-methylcephem hydroxylase
DACS
DAOC hydroxylase
deacetoxycephalosporin C hydroxylase
deacetylcephalosporin C synthase
Reaction catalysed
2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate
Comment(s)
  • The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly.
  • In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1.
  • It is a separate enzyme in Streptomyces clavuligerus.
Cross-references
BRENDA1.14.11.26
EC2PDB1.14.11.26
ExplorEnz1.14.11.26
PRIAM enzyme-specific profiles1.14.11.26
KEGG Ligand Database for Enzyme Nomenclature1.14.11.26
IUBMB Enzyme Nomenclature1.14.11.26
IntEnz1.14.11.26
MEDLINEFind literature relating to 1.14.11.26
MetaCyc1.14.11.26
Rhea expert-curated reactions1.14.11.26
UniProtKB/Swiss-Prot
P42219, CEFF_AMYLAP42220, CEFF_STRCLP11935, EXPA_HAPCH

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