ENZYME entry: EC 1.14.11.29
Accepted Name |
Hypoxia-inducible factor-proline dioxygenase.
|
Alternative Name(s) |
HIF hydroxylase. |
Reaction catalysed |
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) <=> hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2) |
Cofactor(s) |
Fe(2+); L-ascorbate.
|
Comment(s) |
- Contains iron, and requires ascorbate.
- Specifically hydroxylates a proline residue in HIF-alpha, the alpha
subunit of the transcriptional regulator HIF (hypoxia-inducible
factor), which targets HIF for proteasomal destruction.
- The requirement of oxygen for the hydroxylation reaction enables
animals to respond to hypoxia.
|
Cross-references |
BRENDA | 1.14.11.29 |
EC2PDB | 1.14.11.29 |
ExplorEnz | 1.14.11.29 |
PRIAM enzyme-specific profiles | 1.14.11.29 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.29 |
IUBMB Enzyme Nomenclature | 1.14.11.29 |
IntEnz | 1.14.11.29 |
MEDLINE | Find literature relating to 1.14.11.29 |
MetaCyc | 1.14.11.29 |
Rhea expert-curated reactions | 1.14.11.29 |
UniProtKB/Swiss-Prot |
G5EBV0, EGL9_CAEEL; | Q9GZT9, EGLN1_HUMAN; | Q91YE3, EGLN1_MOUSE; |
P59722, EGLN1_RAT; | Q96KS0, EGLN2_HUMAN; | Q91YE2, EGLN2_MOUSE; |
Q6AYU4, EGLN2_RAT; | Q9H6Z9, EGLN3_HUMAN; | Q91UZ4, EGLN3_MOUSE; |
Q62630, EGLN3_RAT; | Q9NXG6, P4HTM_HUMAN; | Q8BG58, P4HTM_MOUSE; |
|
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