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ENZYME entry: EC 1.14.11.29

Accepted Name
Hypoxia-inducible factor-proline dioxygenase.
Alternative Name(s)
HIF hydroxylase.
Reaction catalysed
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) <=> hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2)
Cofactor(s)
Fe(2+); L-ascorbate.
Comment(s)
  • Contains iron, and requires ascorbate.
  • Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction.
  • The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
Cross-references
BRENDA1.14.11.29
EC2PDB1.14.11.29
ExplorEnz1.14.11.29
PRIAM enzyme-specific profiles1.14.11.29
KEGG Ligand Database for Enzyme Nomenclature1.14.11.29
IUBMB Enzyme Nomenclature1.14.11.29
IntEnz1.14.11.29
MEDLINEFind literature relating to 1.14.11.29
MetaCyc1.14.11.29
Rhea expert-curated reactions1.14.11.29
UniProtKB/Swiss-Prot
G5EBV0, EGL9_CAEEL;  Q9GZT9, EGLN1_HUMAN;  Q91YE3, EGLN1_MOUSE;  
P59722, EGLN1_RAT;  Q96KS0, EGLN2_HUMAN;  Q91YE2, EGLN2_MOUSE;  
Q6AYU4, EGLN2_RAT;  Q9H6Z9, EGLN3_HUMAN;  Q91UZ4, EGLN3_MOUSE;  
Q62630, EGLN3_RAT;  Q9NXG6, P4HTM_HUMAN;  Q8BG58, P4HTM_MOUSE;  

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