ENZYME entry: EC 1.14.11.29

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.29

Accepted Name

hypoxia-inducible factor-proline dioxygenase

Alternative Name(s)

HIF hydroxylase

Reaction catalysed

L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2

Comment(s)

Contains iron, and requires ascorbate.
Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction.
The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

Cross-references

BRENDA

1.14.11.29

EC2PDB

1.14.11.29

ExplorEnz

1.14.11.29

KEGG Ligand Database for Enzyme Nomenclature

1.14.11.29

IUBMB Enzyme Nomenclature

1.14.11.29

MEDLINE

Find literature relating to 1.14.11.29

MetaCyc

1.14.11.29

Rhea expert-curated reactions

1.14.11.29

UniProtKB/Swiss-Prot

G5EBV0, EGL9_CAEEL	Q9GZT9, EGLN1_HUMAN	Q91YE3, EGLN1_MOUSE
P59722, EGLN1_RAT	Q96KS0, EGLN2_HUMAN	Q91YE2, EGLN2_MOUSE
Q6AYU4, EGLN2_RAT	Q9H6Z9, EGLN3_HUMAN	Q91UZ4, EGLN3_MOUSE
Q62630, EGLN3_RAT	Q9NXG6, P4HTM_HUMAN	Q8BG58, P4HTM_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
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