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ENZYME

ENZYME entry: EC 1.14.11.29

Accepted Name
hypoxia-inducible factor-proline dioxygenase
Alternative Name(s)
HIF hydroxylase
Reaction catalysed
2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]
Comment(s)
  • Contains iron, and requires ascorbate.
  • Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction.
  • The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
Cross-references
BRENDA1.14.11.29
EC2PDB1.14.11.29
ExplorEnz1.14.11.29
PRIAM enzyme-specific profiles1.14.11.29
KEGG Ligand Database for Enzyme Nomenclature1.14.11.29
IUBMB Enzyme Nomenclature1.14.11.29
IntEnz1.14.11.29
MEDLINEFind literature relating to 1.14.11.29
MetaCyc1.14.11.29
Rhea expert-curated reactions1.14.11.29
UniProtKB/Swiss-Prot
G5EBV0, EGL9_CAEELQ9GZT9, EGLN1_HUMANQ91YE3, EGLN1_MOUSE
P59722, EGLN1_RATQ96KS0, EGLN2_HUMANQ91YE2, EGLN2_MOUSE
Q6AYU4, EGLN2_RATQ9H6Z9, EGLN3_HUMANQ91UZ4, EGLN3_MOUSE
Q62630, EGLN3_RATQ9NXG6, P4HTM_HUMANQ8BG58, P4HTM_MOUSE

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