ID   1.14.11.30
DE   hypoxia-inducible factor-asparagine dioxygenase.
AN   HIF hydroxylase.
CA   2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] +
CA   O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha
CA   subunit] + CO2 + succinate.
CC   -!- Contains iron, and requires ascorbate.
CC   -!- Catalyzes hydroxylation of an asparagine in the C-terminal
CC       transcriptional activation domain of HIF-alpha, the alpha subunit of
CC       the transcriptional regulator HIF (hypoxia-inducible factor), which
CC       reduces its interaction with the transcriptional coactivator protein
CC       p300.
CC   -!- The requirement of oxygen for the hydroxylation reaction enables
CC       animals to respond to hypoxia.
DR   P59723, HIF1N_DANRE;  Q9NWT6, HIF1N_HUMAN;  Q8BLR9, HIF1N_MOUSE;
//