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ENZYME entry: EC 1.14.11.32

Accepted Name
codeine 3-O-demethylase.
Alternative Name(s)
codeine O-demethylase.
Reaction catalysed
2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate
Comment(s)
  • Requires Fe(2+).
  • Catalyzes a step in morphine biosynthesis.
  • The enzyme also catalyzes the 3-O-demethylation of thebaine to oripavine, with lower efficiency.
Cross-references
BRENDA1.14.11.32
EC2PDB1.14.11.32
ExplorEnz1.14.11.32
PRIAM enzyme-specific profiles1.14.11.32
KEGG Ligand Database for Enzyme Nomenclature1.14.11.32
IUBMB Enzyme Nomenclature1.14.11.32
IntEnz1.14.11.32
MEDLINEFind literature relating to 1.14.11.32
MetaCyc1.14.11.32
Rhea expert-curated reactions1.14.11.32
UniProtKB/Swiss-Prot
D4N502, DIOX3_PAPSO

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