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ENZYME entry: EC 1.14.11.33

Accepted Name
DNA oxidative demethylase.
Alternative Name(s)
alkylated DNA repair protein.
Reaction catalysed
2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate
Comment(s)
  • Activity is slightly stimulated by ascorbate.
  • Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine.
  • It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
Cross-references
BRENDA1.14.11.33
EC2PDB1.14.11.33
ExplorEnz1.14.11.33
PRIAM enzyme-specific profiles1.14.11.33
KEGG Ligand Database for Enzyme Nomenclature1.14.11.33
IUBMB Enzyme Nomenclature1.14.11.33
IntEnz1.14.11.33
MEDLINEFind literature relating to 1.14.11.33
MetaCyc1.14.11.33
Rhea expert-curated reactions1.14.11.33
UniProtKB/Swiss-Prot
Q13686, ALKB1_HUMAN;  P0CB42, ALKB1_MOUSE;  Q9SIE0, ALKB2_ARATH;  
Q58DM4, ALKB2_BOVIN;  Q6NS38, ALKB2_HUMAN;  Q6P6J4, ALKB2_MOUSE;  
Q32L00, ALKB3_BOVIN;  Q96Q83, ALKB3_HUMAN;  Q8K1E6, ALKB3_MOUSE;  
Q5XIC8, ALKB3_RAT;  P0CAT7, ALKB_CAUVC;  B8GWW6, ALKB_CAUVN;  
P05050, ALKB_ECOLI;  P37462, ALKB_SALTY;  

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