Expasy logo

ENZYME

ENZYME entry: EC 1.14.11.33

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.33
Accepted Name
DNA oxidative demethylase
Alternative Name(s)
alkylated DNA repair protein
Reaction catalysed
a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2
Comment(s)
  • Activity is slightly stimulated by ascorbate.
  • Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine.
  • It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
Cross-references
BRENDA1.14.11.33
EC2PDB1.14.11.33
ExplorEnz1.14.11.33
KEGG Ligand Database for Enzyme Nomenclature1.14.11.33
IUBMB Enzyme Nomenclature1.14.11.33
MEDLINEFind literature relating to 1.14.11.33
MetaCyc1.14.11.33
Rhea expert-curated reactions1.14.11.33
UniProtKB/Swiss-Prot
Q13686, ALKB1_HUMANP0CB42, ALKB1_MOUSEQ9SIE0, ALKB2_ARATH
Q58DM4, ALKB2_BOVINQ6NS38, ALKB2_HUMANQ6P6J4, ALKB2_MOUSE
Q32L00, ALKB3_BOVINQ96Q83, ALKB3_HUMANQ8K1E6, ALKB3_MOUSE
Q5XIC8, ALKB3_RATP0CAT7, ALKB_CAUVCB8GWW6, ALKB_CAUVN
P05050, ALKB_ECOLIP37462, ALKB_SALTY

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-