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ENZYME

ENZYME entry: EC 1.14.11.51

Accepted Name
DNA N(6)-methyladenine demethylase
Reaction catalysed
2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate
Comment(s)
Catalyzes oxidative demethylation of DNA N(6)-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
Cross-references
BRENDA1.14.11.51
EC2PDB1.14.11.51
ExplorEnz1.14.11.51
PRIAM enzyme-specific profiles1.14.11.51
KEGG Ligand Database for Enzyme Nomenclature1.14.11.51
IUBMB Enzyme Nomenclature1.14.11.51
IntEnz1.14.11.51
MEDLINEFind literature relating to 1.14.11.51
MetaCyc1.14.11.51
Rhea expert-curated reactions1.14.11.51
UniProtKB/Swiss-Prot
Q13686, ALKB1_HUMANP0CB42, ALKB1_MOUSEQ9NXW9, ALKB4_HUMAN
Q9D8F1, ALKB4_MOUSEQ8MNT9, NMAD1_CAEELM9NEY8, TET_DROME

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