ENZYME entry: EC 1.14.11.51
Accepted Name | |||||||||||
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DNA N(6)-methyladenine demethylase | |||||||||||
Reaction catalysed | |||||||||||
2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate | |||||||||||
Comment(s) | |||||||||||
Catalyzes oxidative demethylation of DNA N(6)-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome. | |||||||||||
Cross-references | |||||||||||
BRENDA | 1.14.11.51 | ||||||||||
EC2PDB | 1.14.11.51 | ||||||||||
ExplorEnz | 1.14.11.51 | ||||||||||
PRIAM enzyme-specific profiles | 1.14.11.51 | ||||||||||
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.51 | ||||||||||
IUBMB Enzyme Nomenclature | 1.14.11.51 | ||||||||||
IntEnz | 1.14.11.51 | ||||||||||
MEDLINE | Find literature relating to 1.14.11.51 | ||||||||||
MetaCyc | 1.14.11.51 | ||||||||||
Rhea expert-curated reactions | 1.14.11.51 | ||||||||||
UniProtKB/Swiss-Prot |
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