ENZYME entry: EC 1.14.11.51
| Accepted Name | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DNA N(6)-methyladenine demethylase | |||||||||||
| Reaction catalysed | |||||||||||
| an N(6)-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO2 | |||||||||||
| Comment(s) | |||||||||||
| Catalyzes oxidative demethylation of DNA N(6)-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome. | |||||||||||
| Cross-references | |||||||||||
| Rhea expert-curated reactions | 1.14.11.51 | ||||||||||
| ExplorEnz | 1.14.11.51 | ||||||||||
| IUBMB Enzyme Nomenclature | 1.14.11.51 | ||||||||||
| UniProtKB/Swiss-Prot |
| ||||||||||
| BRENDA | 1.14.11.51 | ||||||||||
| MetaCyc | 1.14.11.51 | ||||||||||
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.51 | ||||||||||
| EC2PDB | 1.14.11.51 | ||||||||||
| MEDLINE | Find literature relating to 1.14.11.51 | ||||||||||
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