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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.11.51

Accepted Name
DNA N(6)-methyladenine demethylase.
Reaction catalysed
N(6)-methyladenine in DNA + 2-oxoglutarate + O(2) <=> adenine in DNA + formaldehyde + succinate + CO(2)
Cofactor(s)
Fe(3+).
Comment(s)
Catalyzes oxidative demethylation of DNA N(6)-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
Cross-references
BRENDA1.14.11.51
EC2PDB1.14.11.51
ExplorEnz1.14.11.51
PRIAM enzyme-specific profiles1.14.11.51
KEGG Ligand Database for Enzyme Nomenclature1.14.11.51
IUBMB Enzyme Nomenclature1.14.11.51
IntEnz1.14.11.51
MEDLINEFind literature relating to 1.14.11.51
MetaCyc1.14.11.51
UniProtKB/Swiss-Prot
Q13686, ALKB1_HUMAN;  P0CB42, ALKB1_MOUSE;  M9NEY8, DMAD_DROME;  
Q8MNT9, NMAD1_CAEEL;  

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