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ENZYME

ENZYME entry: EC 1.14.11.53

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.53
Accepted Name
mRNA N(6)-methyladenine demethylase
Reaction catalysed
an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2
Comment(s)
  • Catalyzes oxidative demethylation of mRNA N(6)-methyladenine.
  • The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
Cross-references
BRENDA1.14.11.53
EC2PDB1.14.11.53
ExplorEnz1.14.11.53
KEGG Ligand Database for Enzyme Nomenclature1.14.11.53
IUBMB Enzyme Nomenclature1.14.11.53
MEDLINEFind literature relating to 1.14.11.53
MetaCyc1.14.11.53
Rhea expert-curated reactions1.14.11.53
UniProtKB/Swiss-Prot
Q9ZT92, AK10B_ARATHQ9SL49, AKB9B_ARATHG4MZ21, ALKB1_PYRO7
E1BH29, ALKB5_BOVINQ08BA6, ALKB5_DANREQ6P6C2, ALKB5_HUMAN
Q3TSG4, ALKB5_MOUSED3ZKD3, ALKB5_RATQ6GPB5, ALKB5_XENLA
Q66JG8, ALKB5_XENTRA0A9P4XUZ4, ALKBH_CRYP1F1PLN3, FTO_CANLF
Q9C0B1, FTO_HUMANQ8BGW1, FTO_MOUSEQ5R7X0, FTO_PONAB
Q2A121, FTO_RATQ68F54, FTO_XENLA

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