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ENZYME entry: EC 1.14.11.53

Accepted Name
mRNA N(6)-methyladenine demethylase.
Reaction catalysed
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) <=> adenosine in mRNA + formaldehyde + succinate + CO(2)
Cofactor(s)
Fe(3+).
Comment(s)
  • Catalyzes oxidative demethylation of mRNA N(6)-methyladenine.
  • The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
Cross-references
BRENDA1.14.11.53
EC2PDB1.14.11.53
ExplorEnz1.14.11.53
PRIAM enzyme-specific profiles1.14.11.53
KEGG Ligand Database for Enzyme Nomenclature1.14.11.53
IUBMB Enzyme Nomenclature1.14.11.53
IntEnz1.14.11.53
MEDLINEFind literature relating to 1.14.11.53
MetaCyc1.14.11.53
UniProtKB/Swiss-Prot
Q6P6C2, ALKB5_HUMAN;  F1PLN3, FTO_CANLF;  Q9C0B1, FTO_HUMAN;  
Q8BGW1, FTO_MOUSE;  Q5R7X0, FTO_PONAB;  Q2A121, FTO_RAT;  

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