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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.11.54

Accepted Name
mRNA N(1)-methyladenine demethylase.
Alternative Name(s)
ALKBH3.
Reaction catalysed
N(1)-methyladenine in mRNA + 2-oxoglutarate + O(2) <=> adenine in mRNA + formaldehyde + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • Catalyzes oxidative demethylation of mRNA N(1)-methyladenine.
  • The enzyme is also involved in alkylation repair in DNA.
Cross-references
BRENDA1.14.11.54
EC2PDB1.14.11.54
ExplorEnz1.14.11.54
PRIAM enzyme-specific profiles1.14.11.54
KEGG Ligand Database for Enzyme Nomenclature1.14.11.54
IUBMB Enzyme Nomenclature1.14.11.54
IntEnz1.14.11.54
MEDLINEFind literature relating to 1.14.11.54
MetaCyc1.14.11.54
UniProtKB/Swiss-Prot
Q32L00, ALKB3_BOVIN;  Q96Q83, ALKB3_HUMAN;  Q8K1E6, ALKB3_MOUSE;  
Q5XIC8, ALKB3_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
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