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ENZYME entry: EC 1.14.11.6

Accepted Name
Thymine dioxygenase.
Alternative Name(s)
Thymine 7-hydroxylase.
Thymine,2-oxoglutarate dioxygenase.
Reaction catalysed
Thymine + 2-oxoglutarate + O(2) <=> 5-hydroxymethyluracil + succinate + CO(2)
Cofactor(s)
Fe(2+); L-ascorbate.
Comment(s)
  • Also acts on 5-hydroxymethyluracil to oxidize its -CH(2)-OH group first to -CHO and then to -COOH.
  • Formerly EC 1.14.11.5.
Cross-references
BRENDA1.14.11.6
EC2PDB1.14.11.6
ExplorEnz1.14.11.6
PRIAM enzyme-specific profiles1.14.11.6
KEGG Ligand Database for Enzyme Nomenclature1.14.11.6
IUBMB Enzyme Nomenclature1.14.11.6
IntEnz1.14.11.6
MEDLINEFind literature relating to 1.14.11.6
MetaCyc1.14.11.6
Rhea expert-curated reactions1.14.11.6
UniProtKB/Swiss-Prot
Q4DBW3, JBP1A_TRYCC;  Q4DLX9, JBP1B_TRYCC;  Q9U6M2, JBP1_CRIFA;  
A4H5X5, JBP1_LEIBR;  A4HU70, JBP1_LEIIN;  Q4QHM7, JBP1_LEIMA;  
Q9U6M1, JBP1_LEITA;  P86938, JBP1_TRYB2;  P86937, JBP1_TRYBB;  
A4H7G5, JBP2_LEIBR;  A4HVU6, JBP2_LEIIN;  Q4QFY1, JBP2_LEIMA;  
B6EU02, JBP2_LEITA;  Q57X81, JBP2_TRYB2;  Q4DCH3, JBP2_TRYCC;  

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