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ENZYME entry: EC 1.14.11.63

Accepted Name
peptidyl-lysine (3S)-dioxygenase.
Alternative Name(s)
JmjC domain-containing protein 7.
Jumonji domain-containing protein 7.
Reaction catalysed
2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate
Comment(s)
  • Requires iron(II).
  • The enzyme acts on specific lysine residues in its substrates, and is stereo-specific.
  • The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.
Cross-references
BRENDA1.14.11.63
EC2PDB1.14.11.63
ExplorEnz1.14.11.63
PRIAM enzyme-specific profiles1.14.11.63
KEGG Ligand Database for Enzyme Nomenclature1.14.11.63
IUBMB Enzyme Nomenclature1.14.11.63
IntEnz1.14.11.63
MEDLINEFind literature relating to 1.14.11.63
MetaCyc1.14.11.63
Rhea expert-curated reactions1.14.11.63
UniProtKB/Swiss-Prot
P0C870, JMJD7_HUMAN;  P0C872, JMJD7_MOUSE;  

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