ID   1.14.11.65
DE   [histone H3]-dimethyl-L-lysine(9) demethylase.
CA   2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 =
CA   2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate.
CC   -!- Requires iron(II).
CC   -!- This entry describes a group of enzymes that demethylate N-methylated
CC       Lys-9 residues in the tail of the histone protein H3 (H3K9).
CC   -!- This lysine residue can exist in three methylation states (mono-,
CC       di- and trimethylated), but this group of enzymes only act on the the
CC       di- and mono-methylated forms.
CC   -!- The enzymes are dioxygenases and act by hydroxylating the methyl
CC       group, forming an unstable hemiaminal that leaves as formaldehyde,
CC       cf. EC 1.14.11.66.
DR   O43593, HAIR_HUMAN ;  Q61645, HAIR_MOUSE ;  P97609, HAIR_RAT   ;
DR   Q9SSE9, JMJ25_ARATH;  Q8VYB9, JMJ27_ARATH;  Q6IRB8, KD3AA_XENLA;
DR   Q5HZN1, KD3AB_XENLA;  Q5ZIX8, KDM3A_CHICK;  Q9Y4C1, KDM3A_HUMAN;
DR   Q6PCM1, KDM3A_MOUSE;  Q63679, KDM3A_RAT  ;  Q7LBC6, KDM3B_HUMAN;
DR   Q6ZPY7, KDM3B_MOUSE;  Q6ZMT4, KDM7A_HUMAN;  Q3UWM4, KDM7A_MOUSE;
DR   P0CH95, PHF8_DANRE ;  Q9UPP1, PHF8_HUMAN ;  Q80TJ7, PHF8_MOUSE ;
//