ID 1.14.11.66 DE [histone H3]-trimethyl-L-lysine(9) demethylase. CA 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + CA 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + CA 2 succinate. CC -!- Requires iron(II). CC -!- This entry describes a group of enzymes that demethylate N-methylated CC Lys-9 residues in the tail of the histone protein H3 (H3K9). CC -!- This lysine residue can exist in three methylation states (mono-, CC di- and trimethylated), but this group of enzymes only act on the the CC tri- and di-methylated forms. CC -!- The enzymes are dioxygenases and act by hydroxylating the methyl CC group, forming an unstable hemiaminal that leaves as formaldehyde, CC cf. EC 1.14.11.65. DR Q336N8, JM706_ORYSJ; Q9V333, KDM4A_DROME; O75164, KDM4A_HUMAN; DR Q8BW72, KDM4A_MOUSE; Q5RD88, KDM4A_PONAB; Q9V6L0, KDM4B_DROME; DR O94953, KDM4B_HUMAN; Q91VY5, KDM4B_MOUSE; Q9H3R0, KDM4C_HUMAN; DR Q8VCD7, KDM4C_MOUSE; Q6B0I6, KDM4D_HUMAN; Q3U2K5, KDM4D_MOUSE; DR A1A5Q5, KDM4D_RAT ; B2RXH2, KDM4E_HUMAN; A0A1W2PPD8, KDM4F_HUMAN; DR Q9U297, KDM4_CAEEL ; //