ID   1.14.11.68
DE   [histone H3]-trimethyl-L-lysine(27) demethylase.
CA   2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] +
CA   2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] +
CA   2 succinate.
CC   -!- Requires iron(II).
CC   -!- This entry describes a group of enzymes that demethylate N-methylated
CC       L-lysine residues at position 27 of histone H3 (H3K27).
CC   -!- The enzymes are dioxygenases and act by hydroxylating the methyl
CC       group, forming an unstable hemiaminal that leaves as formaldehyde.
CC   -!- They can act on tri- and di-methylated forms, but have no activity
CC       with the mono-methylated form.
DR   Q5N712, JM705_ORYSJ;  Q8RWR1, JMJ30_ARATH;  Q0WVR4, JMJ32_ARATH;
DR   O15550, KDM6A_HUMAN;  O70546, KDM6A_MOUSE;  O15054, KDM6B_HUMAN;
DR   Q5NCY0, KDM6B_MOUSE;  O14607, UTY_HUMAN  ;  P79457, UTY_MOUSE  ;
DR   Q6B4Z3, UTY_PANTR  ;
//