ID 1.14.11.69 DE [histone H3]-trimethyl-L-lysine(36) demethylase. CA 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + CA 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + CA 2 succinate. CC -!- Requires iron(II). CC -!- This entry describes a group of enzymes that demethylate N-methylated CC Lys(36) residues in the tail of the histone protein H3 (H3K36). CC -!- This lysine residue can exist in three methylation states (mono-, CC di- and trimethylated), but this group of enzymes only act on the the CC tri- and di-methylated forms. CC -!- The enzymes are dioxygenases and act by hydroxylating the methyl CC group, forming an unstable hemiaminal that leaves as formaldehyde. CC -!- Since trimethylation of H3K36 enhances transcription, this enzyme CC acts as a transcription repressor. CC -!- The enzymes that possess this activity often also catalyze the CC activity of EC 1.14.11.66, cf. EC 1.14.11.27. DR Q8RWR1, JMJ30_ARATH; Q9V333, KDM4A_DROME; O75164, KDM4A_HUMAN; DR Q8BW72, KDM4A_MOUSE; Q5RD88, KDM4A_PONAB; Q9U297, KDM4_CAEEL ; //