A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.11.7
| Accepted Name |
|---|
| Procollagen-proline 3-dioxygenase.
|
| Alternative Name(s) |
|---|
| Procollagen-proline,2-oxoglutarate 3-dioxygenase. |
| Proline,2-oxoglutarate 3-dioxygenase. |
| Prolyl 3-hydroxylase. |
| Reaction catalysed |
|---|
| L-proline-[procollagen] + 2-oxoglutarate + O(2) <=> trans-3-hydroxy-L-proline-[procollagen] + succinate + CO(2) |
| Cofactor(s) |
|---|
| Fe(2+); L-ascorbate.
|
| Comment(s) |
|---|
- The enzyme forms a complex with protein disulfide isomerase, and is
located in the endoplasmic reticulum.
- It modifies proline residues within the procollagen peptide of
certain collagen types.
- The modification is essential for proper collagen triple helix
formation.
|
| Cross-references |
|---|
| PROSITE | PDOC51471 |
| BRENDA | 1.14.11.7 |
| EC2PDB | 1.14.11.7 |
| ExplorEnz | 1.14.11.7 |
| PRIAM enzyme-specific profiles | 1.14.11.7 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.7 |
| IUBMB Enzyme Nomenclature | 1.14.11.7 |
| IntEnz | 1.14.11.7 |
| MEDLINE | Find literature relating to 1.14.11.7 |
| MetaCyc | 1.14.11.7 |
| UniProtKB/Swiss-Prot |
| Q6JHU8, P3H1_CHICK; | Q32P28, P3H1_HUMAN; | Q3V1T4, P3H1_MOUSE; |
| Q9R1J8, P3H1_RAT; | Q6JHU7, P3H2_CHICK; | Q8IVL5, P3H2_HUMAN; |
| Q8CG71, P3H2_MOUSE; | Q4KLM6, P3H2_RAT; | Q8IVL6, P3H3_HUMAN; |
| Q8CG70, P3H3_MOUSE; |
|
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