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ENZYME

ENZYME entry: EC 1.14.11.7

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.7
Accepted Name
procollagen-proline 3-dioxygenase
Alternative Name(s)
procollagen-proline,2-oxoglutarate 3-dioxygenase
proline,2-oxoglutarate 3-dioxygenase
prolyl 3-hydroxylase
Reaction catalysed
L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2
Comment(s)
  • The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum.
  • It modifies proline residues within the procollagen peptide of certain collagen types.
  • The modification is essential for proper collagen triple helix formation.
Cross-references
BRENDA1.14.11.7
EC2PDB1.14.11.7
ExplorEnz1.14.11.7
KEGG Ligand Database for Enzyme Nomenclature1.14.11.7
IUBMB Enzyme Nomenclature1.14.11.7
MEDLINEFind literature relating to 1.14.11.7
MetaCyc1.14.11.7
Rhea expert-curated reactions1.14.11.7
UniProtKB/Swiss-Prot
Q6JHU8, P3H1_CHICKQ32P28, P3H1_HUMANQ3V1T4, P3H1_MOUSE
Q9R1J8, P3H1_RATQ6JHU7, P3H2_CHICKQ8IVL5, P3H2_HUMAN
Q8CG71, P3H2_MOUSEQ4KLM6, P3H2_RATQ8IVL6, P3H3_HUMAN
Q8CG70, P3H3_MOUSE

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