ENZYME entry: EC 1.14.11.7
Accepted Name |
Procollagen-proline 3-dioxygenase.
|
Alternative Name(s) |
Procollagen-proline,2-oxoglutarate 3-dioxygenase. |
Proline,2-oxoglutarate 3-dioxygenase. |
Prolyl 3-hydroxylase. |
Reaction catalysed |
L-proline-[procollagen] + 2-oxoglutarate + O(2) <=> trans-3-hydroxy-L-proline-[procollagen] + succinate + CO(2) |
Cofactor(s) |
Fe(2+); L-ascorbate.
|
Comment(s) |
- The enzyme forms a complex with protein disulfide isomerase, and is
located in the endoplasmic reticulum.
- It modifies proline residues within the procollagen peptide of
certain collagen types.
- The modification is essential for proper collagen triple helix
formation.
|
Cross-references |
PROSITE | PDOC51471 |
BRENDA | 1.14.11.7 |
EC2PDB | 1.14.11.7 |
ExplorEnz | 1.14.11.7 |
PRIAM enzyme-specific profiles | 1.14.11.7 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.7 |
IUBMB Enzyme Nomenclature | 1.14.11.7 |
IntEnz | 1.14.11.7 |
MEDLINE | Find literature relating to 1.14.11.7 |
MetaCyc | 1.14.11.7 |
Rhea expert-curated reactions | 1.14.11.7 |
UniProtKB/Swiss-Prot |
Q6JHU8, P3H1_CHICK; | Q32P28, P3H1_HUMAN; | Q3V1T4, P3H1_MOUSE; |
Q9R1J8, P3H1_RAT; | Q6JHU7, P3H2_CHICK; | Q8IVL5, P3H2_HUMAN; |
Q8CG71, P3H2_MOUSE; | Q4KLM6, P3H2_RAT; | Q8IVL6, P3H3_HUMAN; |
Q8CG70, P3H3_MOUSE; |
|
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