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ENZYME entry: EC 1.14.11.7

Accepted Name
Procollagen-proline 3-dioxygenase.
Alternative Name(s)
Procollagen-proline,2-oxoglutarate 3-dioxygenase.
Proline,2-oxoglutarate 3-dioxygenase.
Prolyl 3-hydroxylase.
Reaction catalysed
L-proline-[procollagen] + 2-oxoglutarate + O(2) <=> trans-3-hydroxy-L-proline-[procollagen] + succinate + CO(2)
Cofactor(s)
Fe(2+); L-ascorbate.
Comment(s)
  • The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum.
  • It modifies proline residues within the procollagen peptide of certain collagen types.
  • The modification is essential for proper collagen triple helix formation.
Cross-references
PROSITEPDOC51471
BRENDA1.14.11.7
EC2PDB1.14.11.7
ExplorEnz1.14.11.7
PRIAM enzyme-specific profiles1.14.11.7
KEGG Ligand Database for Enzyme Nomenclature1.14.11.7
IUBMB Enzyme Nomenclature1.14.11.7
IntEnz1.14.11.7
MEDLINEFind literature relating to 1.14.11.7
MetaCyc1.14.11.7
Rhea expert-curated reactions1.14.11.7
UniProtKB/Swiss-Prot
Q6JHU8, P3H1_CHICK;  Q32P28, P3H1_HUMAN;  Q3V1T4, P3H1_MOUSE;  
Q9R1J8, P3H1_RAT;  Q6JHU7, P3H2_CHICK;  Q8IVL5, P3H2_HUMAN;  
Q8CG71, P3H2_MOUSE;  Q4KLM6, P3H2_RAT;  Q8IVL6, P3H3_HUMAN;  
Q8CG70, P3H3_MOUSE;  

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