ID   1.14.11.73
DE   [protein]-arginine 3-hydroxylase.
CA   2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-
CA   [protein] + CO2 + succinate.
CC   -!- The enzyme, characterized from humans, catalyzes the stereoselective
CC       formation of the (2S,3R)-hydroxy-L-arginine stereoisomer.
CC   -!- So far the enzyme has been shown to act on two substrates - the 40S
CC       ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a
CC       lower activity, RCCD1, a protein involved in chromatin stability,
CC       which is hydroxylated at R141.
CC   -!- Even though the same stereoisomer is produced by the bacterial
CC       EC 1.14.11.47, the two enzymes do not exhibit any cross-reactivity on
CC       their respective ribosomal protein substrates.
DR   Q1JP61, KDM8_BOVIN ;  Q8N371, KDM8_HUMAN ;  Q9CXT6, KDM8_MOUSE ;
DR   Q497B8, KDM8_RAT   ;
//