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ENZYME

ENZYME entry: EC 1.14.11.78

Accepted Name
(R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase
Reaction catalysed
2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate
Comment(s)
  • Requires Fe(II).
  • The enzyme, found in actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides.
  • The reaction comprises two catalytic cycles, each consuming an oxygen molecule and a 2-oxoglutarate molecule.
  • In the first cycle the substrate is hydroxylated, while in the second cycle the enzyme catalyzes a decarboxylation/oxidation reaction that produces an isonitrile group.
Cross-references
BRENDA1.14.11.78
EC2PDB1.14.11.78
ExplorEnz1.14.11.78
PRIAM enzyme-specific profiles1.14.11.78
KEGG Ligand Database for Enzyme Nomenclature1.14.11.78
IUBMB Enzyme Nomenclature1.14.11.78
IntEnz1.14.11.78
MEDLINEFind literature relating to 1.14.11.78
MetaCyc1.14.11.78
Rhea expert-curated reactions1.14.11.78
UniProtKB/Swiss-Prot
P67756, INLPE_MYCBOB2HKM3, INLPE_MYCMMP9WG82, INLPE_MYCTO
P9WG83, INLPE_MYCTUA0A3B6UEU3, INLPE_STRC4

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