ID   1.14.11.80
DE   methylcytosine dioxygenase.
CA   (1) 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 =
CA   a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate.
CA   (2) 2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 =
CA   a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate.
CA   (3) 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 =
CA   a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate.
CC   -!- The TET proteins mediate iterative oxidation of 5-methylcytosine in
CC       DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC),
CC       and 5-carboxylcytosine (5caC).
CC   -!- 5fC and 5caC are recognized by EC 3.2.2.29, which excises them,
CC       leaving an apyrimidinic site.
CC   -!- Coupled with the base excision repair (BER) pathway, these activities
CC       result in a cytosine demethylation pathway.
CC   -!- Formerly EC 1.14.11.n2.
DR   Q8NFU7, TET1_HUMAN ;  Q3URK3, TET1_MOUSE ;  D2W6T1, TET1_NAEGR ;
DR   Q6N021, TET2_HUMAN ;  Q4JK59, TET2_MOUSE ;  A0A1L8GSA2, TET3A_XENLA;
DR   K9JHZ4, TET3B_XENLA;  O43151, TET3_HUMAN ;  Q8BG87, TET3_MOUSE ;
DR   A0JP82, TET3_XENTR ;  M9NEY8, TET_DROME  ;
//