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ENZYME

ENZYME entry: EC 1.14.11.81

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.81
Accepted Name
(-)-cyclopenine synthase
Reaction catalysed
  • (-)-cyclopeptine + 2-oxoglutarate + O2 = (Z)-dehydrocyclopeptine + succinate + CO2 + H2O
  • (Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-cyclopenine + succinate + CO2
Comment(s)
  • This fungal enzyme is involved in the biosynthesis of quinolone compounds.
  • it catalyzes two oxidation reactions: the first reaction results in a desaturation; the second reaction is a monooxygenation of the double bond, forming an epoxide.
  • The enzyme is also active with 4'-methoxycyclopeptine.
Cross-references
Rhea expert-curated reactions1.14.11.81
ExplorEnz1.14.11.81
IUBMB Enzyme Nomenclature1.14.11.81
UniProtKB/Swiss-Prot
Q5AR53, ASQJ_EMENI
BRENDA1.14.11.81
MetaCyc1.14.11.81
KEGG Ligand Database for Enzyme Nomenclature1.14.11.81
EC2PDB1.14.11.81
MEDLINEFind literature relating to 1.14.11.81

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