Expasy logo

ENZYME

ENZYME entry: EC 1.14.11.81

Accepted Name
(-)-cyclopenine synthase
Reaction catalysed
  • (-)-cyclopeptine + 2-oxoglutarate + O2 = (Z)-dehydrocyclopeptine + CO2 + H2O + succinate
  • (Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-cyclopenine + CO2 + succinate
Comment(s)
  • This fungal enzyme is involved in the biosynthesis of quinolone compounds.
  • it catalyzes two oxidation reactions: the first reaction results in a desaturation; the second reaction is a monooxygenation of the double bond, forming an epoxide.
  • The enzyme is also active with 4'-methoxycyclopeptine.
Cross-references
BRENDA1.14.11.81
EC2PDB1.14.11.81
ExplorEnz1.14.11.81
PRIAM enzyme-specific profiles1.14.11.81
KEGG Ligand Database for Enzyme Nomenclature1.14.11.81
IUBMB Enzyme Nomenclature1.14.11.81
IntEnz1.14.11.81
MEDLINEFind literature relating to 1.14.11.81
MetaCyc1.14.11.81
Rhea expert-curated reactions1.14.11.81
UniProtKB/Swiss-Prot
Q5AR53, ASQJ_EMENI

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-