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ENZYME entry: EC 1.14.12.13

Accepted Name
2-halobenzoate 1,2-dioxygenase.
Alternative Name(s)
2-chlorobenzoate 1,2-dioxygenase.
Reaction catalysed
A 2-halobenzoate + NADH + O(2) <=> catechol + a halide anion + NAD(+) + CO(2)
Cofactor(s)
Fe cation.
Comment(s)
  • A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component.
  • The latter contains FAD.
  • The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity.
  • Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference.
Cross-references
BRENDA1.14.12.13
EC2PDB1.14.12.13
ExplorEnz1.14.12.13
PRIAM enzyme-specific profiles1.14.12.13
KEGG Ligand Database for Enzyme Nomenclature1.14.12.13
IUBMB Enzyme Nomenclature1.14.12.13
IntEnz1.14.12.13
MEDLINEFind literature relating to 1.14.12.13
MetaCyc1.14.12.13
Rhea expert-curated reactions1.14.12.13
UniProtKB/Swiss-Prot
Q51601, CBDA_BURCE;  Q51602, CBDB_BURCE;  

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