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ENZYME

ENZYME entry: EC 1.14.12.19

PURL: https://purl.expasy.org/enzyme/EC/1.14.12.19
Accepted Name
3-phenylpropanoate dioxygenase
Alternative Name(s)
3-phenylpropionate dioxygenase
HcaA1A2CD
Hca dioxygenase
Reaction catalysed
  • 3-phenylpropanoate + NADH + O2 + H(+) = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)
  • (E)-cinnamate + NADH + O2 + H(+) = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)
Comment(s)
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
  • It catalyzes the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3- phenylprop-2-enoate.
Cross-references
BRENDA1.14.12.19
EC2PDB1.14.12.19
ExplorEnz1.14.12.19
KEGG Ligand Database for Enzyme Nomenclature1.14.12.19
IUBMB Enzyme Nomenclature1.14.12.19
MEDLINEFind literature relating to 1.14.12.19
MetaCyc1.14.12.19
Rhea expert-curated reactions1.14.12.19
UniProtKB/Swiss-Prot
P0ABR6, HCAE_ECO57A8A344, HCAE_ECOHSP0ABR5, HCAE_ECOLI
Q7N4W0, HCAE_PHOLLQ31XV2, HCAE_SHIBSQ0T1Y1, HCAE_SHIF8
Q83K39, HCAE_SHIFLQ3YZ15, HCAE_SHISSA7ZPY2, HCAF_ECO24
B7LDD1, HCAF_ECO55Q8XA73, HCAF_ECO57B5Z112, HCAF_ECO5E
B7NRI8, HCAF_ECO7IB7M7P2, HCAF_ECO8AC4ZXB4, HCAF_ECOBW
B1XB14, HCAF_ECODHA8A345, HCAF_ECOHSB1IVT8, HCAF_ECOLC
Q47140, HCAF_ECOLIB7N6C6, HCAF_ECOLUB6I5B2, HCAF_ECOSE
B1LNJ5, HCAF_ECOSMQ7N4V9, HCAF_PHOLLQ31XV1, HCAF_SHIBS
Q0T1Y0, HCAF_SHIF8Q83K38, HCAF_SHIFLQ3YZ14, HCAF_SHISS

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