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ENZYME entry: EC 1.14.12.19

Accepted Name
3-phenylpropanoate dioxygenase.
Alternative Name(s)
3-phenylpropionate dioxygenase.
Hca dioxygenase.
HcaA1A2CD.
Reaction catalysed
  • 3-phenylpropanoate + NADH + O(2) <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)
  • (2E)-3-phenylprop-2-enoate + NADH + O(2) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+)
Cofactor(s)
Fe cation.
Comment(s)
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
  • It catalyzes the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3- phenylprop-2-enoate.
Cross-references
PROSITEPDOC00493
BRENDA1.14.12.19
EC2PDB1.14.12.19
ExplorEnz1.14.12.19
PRIAM enzyme-specific profiles1.14.12.19
KEGG Ligand Database for Enzyme Nomenclature1.14.12.19
IUBMB Enzyme Nomenclature1.14.12.19
IntEnz1.14.12.19
MEDLINEFind literature relating to 1.14.12.19
MetaCyc1.14.12.19
Rhea expert-curated reactions1.14.12.19
UniProtKB/Swiss-Prot
P0ABR6, HCAE_ECO57;  A8A344, HCAE_ECOHS;  P0ABR5, HCAE_ECOLI;  
Q7N4W0, HCAE_PHOLL;  Q31XV2, HCAE_SHIBS;  Q0T1Y1, HCAE_SHIF8;  
Q83K39, HCAE_SHIFL;  Q3YZ15, HCAE_SHISS;  A7ZPY2, HCAF_ECO24;  
B7LDD1, HCAF_ECO55;  Q8XA73, HCAF_ECO57;  B5Z112, HCAF_ECO5E;  
B7NRI8, HCAF_ECO7I;  B7M7P2, HCAF_ECO8A;  C4ZXB4, HCAF_ECOBW;  
B1XB14, HCAF_ECODH;  A8A345, HCAF_ECOHS;  B1IVT8, HCAF_ECOLC;  
Q47140, HCAF_ECOLI;  B7N6C6, HCAF_ECOLU;  B6I5B2, HCAF_ECOSE;  
B1LNJ5, HCAF_ECOSM;  Q7N4V9, HCAF_PHOLL;  Q31XV1, HCAF_SHIBS;  
Q0T1Y0, HCAF_SHIF8;  Q83K38, HCAF_SHIFL;  Q3YZ14, HCAF_SHISS;  

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