ENZYME entry: EC 1.14.12.23
| Accepted Name |
|---|
| Nitroarene dioxygenase.
|
| Reaction catalysed |
|---|
| Nitrobenzene + NADH + O(2) <=> catechol + nitrite + NAD(+) |
| Cofactor(s) |
|---|
| Fe(2+).
|
| Comment(s) |
|---|
- This enzyme is a member of the naphthalene family of bacterial Rieske
non-heme iron dioxygenases.
- It comprises a multicomponent system, containing a Rieske [2Fe-2S]
ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3),
and an alpha-3-beta-3 oxygenase.
- The enzyme forms of a cis-dihydroxylated product that spontaneously
rearranges to form a catechol with accompanying release of nitrite.
- It can typically act on many different nitroaromatic compounds,
including chlorinated species.
- Enzymes found in different strains may have different substrate
preferences.
|
| Cross-references |
|---|
| BRENDA | 1.14.12.23 |
| EC2PDB | 1.14.12.23 |
| ExplorEnz | 1.14.12.23 |
| PRIAM enzyme-specific profiles | 1.14.12.23 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.12.23 |
| IUBMB Enzyme Nomenclature | 1.14.12.23 |
| IntEnz | 1.14.12.23 |
| MEDLINE | Find literature relating to 1.14.12.23 |
| MetaCyc | 1.14.12.23 |
| Rhea expert-curated reactions | 1.14.12.23 |
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