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ENZYME entry: EC 1.14.12.23

Accepted Name
Nitroarene dioxygenase.
Reaction catalysed
Nitrobenzene + NADH + O(2) <=> catechol + nitrite + NAD(+)
Cofactor(s)
Fe(2+).
Comment(s)
  • This enzyme is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases.
  • It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3), and an alpha-3-beta-3 oxygenase.
  • The enzyme forms of a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite.
  • It can typically act on many different nitroaromatic compounds, including chlorinated species.
  • Enzymes found in different strains may have different substrate preferences.
Cross-references
BRENDA1.14.12.23
EC2PDB1.14.12.23
ExplorEnz1.14.12.23
PRIAM enzyme-specific profiles1.14.12.23
KEGG Ligand Database for Enzyme Nomenclature1.14.12.23
IUBMB Enzyme Nomenclature1.14.12.23
IntEnz1.14.12.23
MEDLINEFind literature relating to 1.14.12.23
MetaCyc1.14.12.23
Rhea expert-curated reactions1.14.12.23

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