ENZYME entry: EC 1.14.13.101
| Accepted Name |
|---|
| Senecionine N-oxygenase.
|
| Alternative Name(s) |
|---|
| Senecionine monooxygenase (N-oxide-forming). |
| Reaction catalysed |
|---|
| Senecionine + NADPH + O(2) <=> senecionine N-oxide + NADP(+) + H(2)O |
| Comment(s) |
|---|
- NADH cannot replace NADPH.
- While pyrrolizidine alkaloids of the senecionine and monocrotaline
types are generally good substrates (e.g. senecionine, retrorsine and
monocrotaline), the enzyme does not use ester alkaloids lacking an
hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-
alkaloids (e.g. sarracine) or unesterified necine bases (e.g.
senkirkine) as substrates.
- Senecionine N-oxide is used by insects as a chemical defense: it is
non-toxic, but it is bioactivated to a toxic form by the action of
cytochrome P450 oxidase when absorbed by insectivores.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.101 |
| EC2PDB | 1.14.13.101 |
| ExplorEnz | 1.14.13.101 |
| PRIAM enzyme-specific profiles | 1.14.13.101 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.101 |
| IUBMB Enzyme Nomenclature | 1.14.13.101 |
| IntEnz | 1.14.13.101 |
| MEDLINE | Find literature relating to 1.14.13.101 |
| MetaCyc | 1.14.13.101 |
| UniProtKB/Swiss-Prot |
|
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