ENZYME entry: EC 1.14.13.101
Accepted Name |
Senecionine N-oxygenase.
|
Alternative Name(s) |
Senecionine monooxygenase (N-oxide-forming). |
Reaction catalysed |
Senecionine + NADPH + O(2) <=> senecionine N-oxide + NADP(+) + H(2)O |
Comment(s) |
- NADH cannot replace NADPH.
- While pyrrolizidine alkaloids of the senecionine and monocrotaline
types are generally good substrates (e.g. senecionine, retrorsine and
monocrotaline), the enzyme does not use ester alkaloids lacking an
hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-
alkaloids (e.g. sarracine) or unesterified necine bases (e.g.
senkirkine) as substrates.
- Senecionine N-oxide is used by insects as a chemical defense: it is
non-toxic, but it is bioactivated to a toxic form by the action of
cytochrome P450 oxidase when absorbed by insectivores.
|
Cross-references |
BRENDA | 1.14.13.101 |
EC2PDB | 1.14.13.101 |
ExplorEnz | 1.14.13.101 |
PRIAM enzyme-specific profiles | 1.14.13.101 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.101 |
IUBMB Enzyme Nomenclature | 1.14.13.101 |
IntEnz | 1.14.13.101 |
MEDLINE | Find literature relating to 1.14.13.101 |
MetaCyc | 1.14.13.101 |
Rhea expert-curated reactions | 1.14.13.101 |
UniProtKB/Swiss-Prot |
|
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