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ENZYME

ENZYME entry: EC 1.14.13.148

Accepted Name
trimethylamine monooxygenase
Alternative Name(s)
flavin-containing monooxygenase 3
Reaction catalysed
NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide
Comment(s)
  • The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy.
  • The mammalian enzyme is involved in detoxification of trimethylamine.
  • Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome).
Cross-references
BRENDA1.14.13.148
EC2PDB1.14.13.148
ExplorEnz1.14.13.148
PRIAM enzyme-specific profiles1.14.13.148
KEGG Ligand Database for Enzyme Nomenclature1.14.13.148
IUBMB Enzyme Nomenclature1.14.13.148
IntEnz1.14.13.148
MEDLINEFind literature relating to 1.14.13.148
MetaCyc1.14.13.148
Rhea expert-curated reactions1.14.13.148
UniProtKB/Swiss-Prot
Q95LA2, FMO1_CANLFQ01740, FMO1_HUMANP50285, FMO1_MOUSE
P16549, FMO1_PIGP17636, FMO1_RABITP36365, FMO1_RAT
Q8HYJ9, FMO3_BOVINQ95LA1, FMO3_CANLFP49328, FMO3_CAVPO
P31513, FMO3_HUMANQ8SPQ7, FMO3_MACMUP97501, FMO3_MOUSE
Q7YS44, FMO3_PANTRP32417, FMO3_RABITQ9EQ76, FMO3_RAT

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